Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions.
Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding Questions.
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NANOG 在癌症干细胞和肿瘤发展中的作用：更新和悬而未决的问题
DOI：
10.1002/stem.2007
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Tang DG
中科院分区：
文献类型：
--
作者：
Jeter CR;Yang T;Wang J;Chao HP;Tang DG
同源异型框结构域转录因子NANOG是胚胎发育和细胞重编程的关键调节因子，据报道在人类癌症中广泛表达。功能研究提供了强有力的证据表明，NANOG具有促肿瘤属性。除了促进干细胞样癌细胞的自我更新和长期增殖潜力外，NANOG介导的致癌重编程可能是恶性疾病临床表现的基础。在这篇综述中，我们研究了NANOG在各种恶性肿瘤中的分子起源、表达、生物学活性和作用机制。我们还考虑了临床意义，例如NANOG表达与癌症预后和/或对治疗的反应之间的相关性。我们推测，NANOG增强了肿瘤发生的分子电路，因此可能代表癌症诊断、预后和治疗结果的新的治疗靶点或生物标志物。最后，我们提出了有关NANOG癌症干细胞和肿瘤发展的关键悬而未决的问题。
The homeobox domain transcription factor NANOG, a key regulator of embryonic development and cellular reprogramming, has been reported to be broadly expressed in human cancers. Functional studies have provided strong evidence that NANOG possesses protumorigenic attributes. In addition to promoting self-renewal and long-term proliferative potential of stem-like cancer cells, NANOG-mediated oncogenic reprogramming may underlie clinical manifestations of malignant disease. In this review, we examine the molecular origin, expression, biological activities and mechanisms of action of NANOG in various malignancies. We also consider clinical implications such as correlations between NANOG expression and cancer prognosis and/or response to therapy. We surmise that NANOG potentiates the molecular circuitry of tumorigenesis, and thus may represent a novel therapeutic target or biomarker for the diagnosis, prognosis and treatment outcome of cancer. Finally, we present critical pending questions relating NANOG to cancer stem cells and tumor development.