Determination of the sensitivity and specificity of sibship calculations using AmpF/STR Profiler Plus
Determination of the sensitivity and specificity of sibship calculations using AmpF/STR Profiler Plus
复制标题
DOI：
10.1007/s00414-001-0273-8
复制
发表时间：
2002-06-01
影响因子：
2.1
通讯作者：
Pretty, IA
中科院分区：
文献类型：
--
作者：
Gaytmenn, R;Hildebrand, DP;Pretty, IA
在无法从死者的财物或亲生父母获得已知DNA参考样本的情况下，可以进行更复杂的亲属关系分析。本文报道的工作目的是利用多个STR基因座确定手足关系分析的敏感性和特异性。使用所有9个Profiler Plus基因座，生物学上相关的兄弟姐妹的似然比从略小于1到超过45000不等。当等位基因缺失被模拟时，可能性比从小于1到大于1000不等。因此，本研究的结果有一个直接应用到法医实验室面临的鉴定涉及兄弟姐妹比较。
In circumstances where a known DNA reference sample from the deceased's belongings or biological parents is not available, more complex kinship analyses are possible. The purpose of the work reported here is to determine the sensitivity and specificity of the sibship analysis utilising multiple STR loci. Using all nine Profiler Plus loci, likelihood ratios for biologically-related siblings ranged from slightly less than 1 to over 45,000. When allelic dropout was mimicked, likelihood ratios ranged from less than I to over 1,000. Thus, the results of this study have a direct application to forensic laboratories faced with identifications involving sibling comparisons.