Understanding antibiotic resistance via outer membrane permeability.
Understanding antibiotic resistance via outer membrane permeability.
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DOI：
10.2147/idr.s156995
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发表时间：
2018
影响因子：
3.9
通讯作者：
Ghai S
中科院分区：
文献类型：
--
作者：
Ghai I;Ghai S
集体抗生素耐药性是一个全球性的威胁，特别是对于革兰氏阴性菌。细菌外细胞壁的低渗透性已被确定为具有挑战性的屏障，其阻止在低剂量抗生素下获得足够的抗生素效果。革兰氏阴性细菌细胞被膜包括将周质与外部环境划界的外膜。抗生素通过外膜进入的关键机制包括负责亲水性抗生素的一般扩散孔蛋白（Omps）和负责疏水性抗生素的脂质介导途径。外膜的蛋白质和脂质排列对理解细菌及其对许多类型抗生素的抗性产生了强烈的影响。因此，目前的挑战之一是有效的解释外膜渗透性的分子基础。这篇综述试图发展一个国家的知识有关的Omps和溶质流入的有效作用。此外，它的目的是进一步了解和探索的前景，以提高我们的知识的物理化学限制，直接通过细菌外膜的抗生素易位。
Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.