Endothelin receptors in kainic acid-induced neural lesions of rat brain
Endothelin receptors in kainic acid-induced neural lesions of rat brain
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红藻氨酸诱导的大鼠脑神经损伤中的内皮素受体
DOI：
10.1016/s0306-4522(97)00175-9
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发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
K. Taniyama
中科院分区：
文献类型：
--
作者：
Y. Sakurai‐Yamashita;M. Niwa;K. Yamashita;Y. Kataoka;A. Himeno;K. Shigematsu;K. Tsutsumi;K. Taniyama
在侧脑室注射0.8μg红藻氨酸（kainicacid）后7天，即损伤后神经组织修复的时间，我们应用受体放射自显影方法检测了红藻氨酸诱导的大鼠脑神经损伤中内皮素受体的变化。在受损的海马CA 1、CA 3和CA 4亚区中有带状区域，其具有新生表达的[125 I]内皮素-1结合位点。我们还注意到一个低结合密度的均匀区，该区域被带状区域夹在中间。在解剖学上对应于梨状皮质深层索马层和杏仁复合体外侧部分的“远端”区域，我们注意到一个具有低密度[125 I]内皮素-1结合位点的“穿孔图”的明确区域。病变周围是富含结合位点的区域。新表达的[125 I]内皮素-1结合位点被鉴定为内皮素B受体。小胶质细胞主要分布在“穿孔”区和海马锥体细胞层，神经元死亡。与小胶质细胞相反，在红藻氨酸诱导的神经病变中，星形胶质细胞在解剖学上对应于具有新生内皮素B受体的区域中富含肥大。结合目前观察到的细胞分布的显微证据，我们认为新生表达的内皮素B受体是由聚集在神经病变中的星形胶质细胞携带的。根据我们的研究结果，星形胶质细胞在神经元损伤后对神经组织修复的反应中可以被内皮素B受体激活的可能性将不得不被考虑。
Seven days after an intracerebroventricular injection of 0.8μg kainic acid, a time of neural tissue-repair after damage, we applied our receptor autoradiographic method to examine changes in the endothelin receptors in kainic acid-induced neural lesions of the rat brain. There were belt-shaped areas with the de novo expressed [125I]endothelin-1 binding sites in the damaged hippocampus CA1, CA3, and CA4 subfields. We also noted a homogeneous zone with a low binding-density, the area sandwiched by the belt-shaped areas. In a “remote” area corresponding anatomically to the deep soma layer of the piriform cortex plus lateral parts of amygdaloid complex we noted a well-defined area with “punched hole-figure” of low density [125I]endothelin-1 binding sites. The lesion was surrounded by areas rich in binding sites. The de novo expressed [125I]endothelin-1 binding sites were characterized endothelinBreceptor. Microglia were present in the area with “punched hole-figure” and in the hippocampus pyramidal cell layer with neuronal death. In contrast to microglia, astrocytes were rich with hypertrophia in kainic acid-induced neural lesions anatomically corresponding to areas with the de novo endothelinBreceptor. Taken together with the present observations of microscopic evidence of cellular distribution, we suggest that the de novo expressed endothelinBreceptor was carried by astrocytes aggregating in neural lesions. In light of our findings, the possibility that astrocytes can be activated by the endothelinBreceptor in response to neural tissue repair after damage to neurons would have to be considered.
HIV-1 糖蛋白 120 有效刺激单核细胞内皮素 1 的产生。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ehrenreich,H;Rieckmann,P;Sinowatz,F;Weih,KA;Arthur,LO;Goebel,FD;Burd,PR;Coligan,JE;Clouse,KA
通讯作者：
Clouse,KA
DOI：
10.1073/pnas.87.6.2359
发表时间：
1990-03-01
影响因子：
11.1
作者：
MACCUMBER, MW;ROSS, CA;SNYDER, SH
通讯作者：
SNYDER, SH