Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China
Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China
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DOI：
10.1620/tjem.226.11
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发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
Wang, Shijie
中科院分区：
文献类型：
--
作者：
Zhang, Nan;Yu, Cao;Wang, Shijie
食管鳞状细胞癌（ESCC）是全球第八大常见恶性肿瘤，在中国发病率最高。本研究旨在通过地理空间分析探讨饮用水中的含氮化合物与ESCC发病率之间的关联。中国歙县的ESCC发病率较高，环境因素，尤其是受氮污染的饮用水，是主要的可疑风险因素。本研究关注饮用水中的三种含氮化合物，即硝酸盐、亚硝酸盐和氨，它们主要来源于生活垃圾和农业化肥。该研究调查了歙县地区的48个村庄，总人口为54716人（661名ESCC成人患者和54055名非癌症受试者）。热点分析用于确定ESCC高发且含氮化合物浓度高的空间聚集区域。逻辑回归分析用于检测ESCC发病的风险因素。饮用水中硝酸盐氮浓度高的大部分地区ESCC发病率较高。相关性分析显示硝酸盐浓度与ESCC之间存在显著正相关（P = 0.01）。逻辑回归分析还证实硝酸盐氮的优势比显著更高。结果表明歙县的硝酸盐氮与ESCC发病率相关。总之，饮用水中高浓度的硝酸盐氮可能是ESCC发病的一个重要风险因素。
The incidence of esophageal squamous cell carcinoma (ESCC), which is the eighth most common malignancy worldwide, is highest in China. The purpose of this study was to investigate the association between nitrogen compounds in drinking water with the incidence of ESCC by geographical spatial analysis. The incidence of ESCC is high in Shexian county, China, and environmental factors, particularly nitrogen-contaminated drinking water, are the main suspected risk factors. This study focuses on three nitrogen compounds in drinking water, namely, nitrates, nitrites, and ammonia, all of which are derived mainly from domestic garbage and agricultural fertilizer. The study surveyed 48 villages in the Shexian area with a total population of 54,716 (661 adults with ESCC and 54,055 non-cancer subjects). Hot-spot analysis was used to identify spatial clusters with a high incidence of ESCC and a high concentration of nitrogen compounds. Logistic regression analysis was used to detect risk factors for ESCC incidence. Most areas with high concentrations of nitrate nitrogen in drinking water had a high incidence of ESCC. Correlation analysis revealed a significant positive relationship between nitrate concentration and ESCC (P = 0.01). Logistic regression analysis also confirmed that nitrate nitrogen has a significantly higher odds ratio. The results indicate that nitrate nitrogen is associated with ESCC incidence in Shexian county. In conclusion, high concentrations of nitrate nitrogen in drinking water may be a significant risk factor for the incidence of ESCC.