Cardiovascular morbidity and mortality associated with the metabolic syndrome
Cardiovascular morbidity and mortality associated with the metabolic syndrome
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DOI：
10.2337/diacare.24.4.683
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发表时间：
2001-04-01
期刊：
影响因子：
16.2
通讯作者：
Groop, L
中科院分区：
文献类型：
--
作者：
Isomaa, B;Almgren, P;Groop, L
目的：使用世界卫生组织（WHO）提出的新定义估计代谢综合征的患病率和心血管风险。研究设计和方法：共有4483名年龄在35-70岁之间的受试者参加了芬兰和瑞典的一项大型2型糖尿病家庭研究（Botnia研究），纳入了与代谢综合征相关的心血管风险分析。在1697例2型糖尿病患者中，空腹血糖(IFG)/糖耐量（IGT）受损（n = 798），或胰岛素抵抗伴正常糖耐量（NGT） （n = 1988）。代谢综合征被定义为至少存在以下两种危险因素：肥胖、高血压、血脂异常或微量白蛋白尿。对3606名受试者的心血管死亡率进行了评估，中位随访时间为6.9年。结果：在女性和男性中，分别有10%和15%的NGT患者出现代谢综合征。IFG/IGT患者分别为42%和64%，2型糖尿病患者分别为78%和84%。冠状动脉粥样硬化综合征患者发生冠心病和中风的风险增加了3倍（P < 0.001）。代谢综合征患者的心血管死亡率显著增加（12.0 vs. 2.2%, P < 0.001）。在代谢综合征的各个组成部分中，微量白蛋白尿导致心血管死亡的风险最高（RR 2.80）。P = 0.002)。结论：世卫组织对代谢综合征的定义确定了心血管发病率和死亡率增加的受试者，并提供了一种比较不同研究结果的工具。
OBJECTIVE - To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organisation (WHO).RESEARCH DESIGN AND METHODS - A total of 4,483 subjects aged 35-70 years participating in a large family study of type 2 diabetes in Finland and Sweden (the Botnia study) were included in the analysis of cardiovascular risk associated with the metabolic syndrome. in subjects who had type 2 diabetes in = 1,697) impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) (n = 798), or insulin-resistance with normal glucose tolerance (NGT) (n = 1,988). the metabolic syndrome was de fined as presence of at least two of the following risk factors: obesity hypertension, dyslipidemia, or microalbuminuria. Cardiovascular mortality was assessed in 3,606 subjects with a median follow-up of 6.9 years.RESULTS - In women and men, respectively, the metabolic syndrome was seen in 10 and 15% of subjects with NGT. 42 and 64% of those with IFG/IGT, and 78 and 84% of those with type 2 diabetes. The risk for coronary heart disease and stroke was increased threefold in subjects with the syndrome (P < 0.001). Cardiovascular mortality was markedly increased in subjects with the metabolic syndrome (12.0 vs. 2.2%, P < 0.001) Of the individual components of the metabolic syndrome, microalbuminuria conferred the strongest risk of cardiovascular death (RR 2.80. P = 0.002).CONCLUSIONS - The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from different studies.