Three-dimensional registration of prostate images from histology and ultrasound
Three-dimensional registration of prostate images from histology and ultrasound
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DOI：
10.1016/j.ultrasmedbio.2003.10.005
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发表时间：
2004-02-01
影响因子：
2.9
通讯作者：
Parker, KJ
中科院分区：
文献类型：
--
作者：
Taylor, LS;Porter, BC;Parker, KJ
一个完整的安装组织学协议的3-D组织重建，以比较的大小和空间位置的肿瘤（和其他组件）的组织学数据中确定的3-D超声（US）图像。前列腺标本的三维成像使用B型（US）和超声弹性成像。在每个B模式图像中描绘前列腺表面的轮廓，并进行3D表面重建。然后准备标本进行全封片组织学检查，并对组织学载玻片进行数字重建以制作3D表面。这两个表面，然后使用3-D相关算法对齐，并确定由病理学家的肿瘤边界进行比较，使用sonoelastography。显示一个前列腺的前列腺表面重建的重叠组织学和声弹性成像的3-D图像被提出来说明该技术;四个前列腺的结果产生了92% +/-3%的准确性。
A whole mount histology protocol for 3-D tissue reconstruction to compare the size and spatial location of tumors (and other components) identified in histology data with that from 3-D ultrasound (US) images is presented. Prostate specimens are imaged in 3-D using B-mode (US) and sonoelastography. The prostate surface is outlined in each B-mode image and a 3-D surface reconstruction is made. The specimen is then prepared for whole mount histology and the histology slides are digitally reconstructed to make a 3-D surface. These two surfaces are then aligned using a 3-D correlation algorithm, and the tumor boundary determined by the pathologist is compared with that using sonoelastography. 3-D images showing the overlapping histology and sonoelastography of prostate surface reconstructions for one prostate are presented to illustrate the technique; results for four prostates yielded an accuracy of 92% +/- 3%.