Genetic variation of new 21 autosomal short tandem repeat loci in a Chinese Salar ethnic group
Genetic variation of new 21 autosomal short tandem repeat loci in a Chinese Salar ethnic group
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中国撒拉族21个常染色体短串联重复序列新位点的遗传变异
DOI：
10.1007/s11033-011-0883-2
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发表时间：
2012-02-01
影响因子：
2.8
通讯作者：
Liu, Jian-ling
中科院分区：
文献类型：
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作者：
Teng, Yan;Zhang, Fei-xiong;Liu, Jian-ling
在本研究中，我们报告了新的 21 个常染色体短串联重复 (STR) 位点的等位基因频率，包括 D6S474、D12ATA63、D22S1045、D10S1248、D1S1677、D11S4463、D1S1627、D3S4529、D2S441、D6S1017、 D4S2408、D19S433、D17S1301、D1GATA113、D18S853、D20S482、D14S1434、D9S1122、D2S1776、D10S1435 和 D5S2500 基因座。法医统计参数是根据来自中国青海省循化撒拉族自治县撒拉族的 120 名无关健康个体的样本集进行估计的。人群中21个STR位点共观察到151个等位基因，其等位基因频率在0.004~0.554之间。所有STR位点均表现出高度的遗传多态性，所有21个STR位点的组合排除概率、组合辨别力和组合匹配概率分别为0.9999993134、0.99999999999999999991739和8.2607×10−20。对于撒拉族的所有21个STR位点，观察到的基因型数据与Hardy-Weinberg平衡下的预期没有显着偏差。比较撒拉族与其邻近人群的21个常染色体STR位点的等位基因频率分布，发现这些人群之间的D1S1677、D2S441、D3S4529、D4S2408、D6S1017、D11S4463、D12ATA63、D14S14343、D18S853、 D19S433 和 D22S1045 基因座。
In the present study, we reported the allele frequencies for new 21 autosomal short tandem repeat (STR) loci, including D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500 loci. Forensic statistical parameters were estimated from a sample set of 120 unrelated healthy individuals from the Salar ethnic group in Xunhua Salar Autonomous County of Qinghai province, China. A total of 151 alleles were observed at 21 STR loci in the population, and their allele frequencies were in the range of 0.004–0.554. All STR loci showed a high degree of genetic polymorphisms, and the combined probability of exclusion, combined power of discrimination and combined probability of matching for all 21 STR loci were 0.9999993134, 0.99999999999999999991739 and 8.2607 × 10−20, respectively. For all the 21 STR loci in the Salar ethnic group, the observed genotypic data showed no significant deviation from those expected under the Hardy-Weinberg equilibrium. The allele frequency distributions for the 21 autosomal STR loci were compared between the Salar group and its neighboring populations and significant differences were detected among these populations at D1S1677, D2S441, D3S4529, D4S2408, D6S1017, D11S4463, D12ATA63, D14S14343, D18S853, D19S433 and D22S1045 loci.