Long-term survival and recurrence after curative resection for hepatocellular carcinoma in patients with chronic hepatitis C virus infection: a multicenter observational study from China.
Long-term survival and recurrence after curative resection for hepatocellular carcinoma in patients with chronic hepatitis C virus infection: a multicenter observational study from China.
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DOI：
10.1016/j.hpb.2020.04.006
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发表时间：
2020-05
期刊：
影响因子：
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通讯作者：
Hong Zhu;H. Xing;Bin Yu;Wen-Tao Yan;Cheng-wu Zhang;Ming-Cheng Guan;Yahao Zhou;Hong Wang;Wan-guang Zhang;Yao-Ming Zhang;Jie-Wei Li;Yu Wang;Ting-Hao Chen;Y. Zeng;W. Lau;L. Liang;Chao Li;Tian Yang
中科院分区：
文献类型：
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作者：
Hong Zhu;H. Xing;Bin Yu;Wen-Tao Yan;Cheng-wu Zhang;Ming-Cheng Guan;Yahao Zhou;Hong Wang;Wan-guang Zhang;Yao-Ming Zhang;Jie-Wei Li;Yu Wang;Ting-Hao Chen;Y. Zeng;W. Lau;L. Liang;Chao Li;Tian Yang
BackgroundHepatocellular carcinoma (HCC) is a recognized sequalae of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study aimed to identify long-term survival and prognostic factors after curative resection for HCC among patients with chronic HCV infection.MethodsFrom a Chinese multicenter database, the data of consecutive patients with HCV infection undergoing curative liver resection for initial HCC between 2006 and 2015 were retrospectively reviewed. Postoperative 30-day mortality and morbidity, long-term overall survival (OS) and recurrence-free survival (RFS) were evaluated.ResultsAmong 382 HCC patients with HCV infection, 68 (18%) had concurrent HBV infection and 110 (29%) had portal hypertension. Postoperative 30-day morbidity and mortality rates were 45% and 2.9%, respectively. The 5-year OS and RFS rates were 45% and 34%, respectively. Multivariable Cox-regression analyses identified that concurrent HBV infection, presence of portal hypertension, largest tumor size > 5 cm, and macrovascular and microvascular invasion were independently associated with worse OS and RFS, while postoperative regular anti-HCV therapy was independently associated with better OS.ConclusionLong-term prognosis after HCC resection among patients with HCV infection was worse in those with concurrent HBV infection and concomitant portal hypertension. Postoperative regular anti-HCV therapy was associated with better OS.
