The origin of word-related motor activity.

The origin of word-related motor activity.
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与单词相关的运动活动的起源。

DOI:
10.1093/cercor/bht423
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发表时间:
2015
期刊:
Cerebral cortex (New York, N.Y. : 1991)
影响因子:
--
通讯作者:
Caramazza,Alfonso
Caramazza,Alfonso
中科院分区:
--
文献类型:
--
作者:
Papeo,Liuba;Lingnau,Angelika;Agosta,Sara;Pascual-Leone,Alvaro;Battelli,Lorella;Caramazza,Alfonso

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动词的概念加工始终使用左侧后颞中回(lpMTG)。左中央前运动皮层对动词也有反应,动作动词比非动作动词更活跃。这种效应的早期时机表明,在lpMTG中,词语意义的运动特征是直接访问的,绕过了对概念表征的访问。另一种假设是,lpMTG中概念表征的检索对于驱动中央前回中更具体的运动相关表征是必要的。为了验证这些假设,我们首先证明,重复经颅磁刺激(rTMS)应用于倾向动词的lpMTG部位,选择性地削弱了动词的语义加工。在第二个实验中,相对于没有刺激(无刺激),rTMS对lpMTG的扰动消除了运动活动中动作-非动作动词的区别,这是通过单脉冲TMS在左初级运动皮层周围肌肉中诱导的运动诱发电位来指示的。相对于非经颅磁刺激,经颅磁刺激对枕部控制部位的干扰不影响运动活动中动作-非动作动词的区分,但动词对比与lpMTG效应没有可靠的差异。结果表明,lpMTG携带了驱动中央前回特定(运动)特征激活所必需的核心语义信息。
Conceptual processing of verbs consistently recruits the left posterior middle temporal gyrus (lpMTG). The left precentral motor cortex also responds to verbs, with higher activity for action than nonaction verbs. The early timing of this effect has suggested that motor features of words' meaning are accessed directly, bypassing access to conceptual representations in lpMTG. An alternative hypothesis is that the retrieval of conceptual representations in lpMTG is necessary to drive more specific, motor-related representations in the precentral gyrus. To test these hypotheses, we first showed that repetitive transcranial magnetic stimulation (rTMS) applied to the verb-preferring lpMTG site selectively impoverished the semantic processing of verbs. In a second experiment, rTMS perturbation of lpMTG, relative to no stimulation (no-rTMS), eliminated the action–nonaction verb distinction in motor activity, as indexed by motor-evoked potentials induced in peripheral muscles with single-pulse TMS over the left primary motor cortex. rTMS pertubation of an occipital control site, relative to no-rTMS, did not affect the action–nonaction verb distinction in motor activity, but the verb contrast did not differ reliably from the lpMTG effect. The results show that lpMTG carries core semantic information necessary to drive the activation of specific (motor) features in the precentral gyrus.
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