Postnatal stress in mice: does "stressing" the mother have the same effect as "stressing" the pups?
Postnatal stress in mice: does "stressing" the mother have the same effect as "stressing" the pups?
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老鼠的产后压力：“给母亲施加压力”与给幼崽“施加压力”有同样的效果吗？
DOI：
10.1002/dev.20008
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发表时间：
2004
影响因子：
2.2
通讯作者：
Francesca R. D'Amato
中科院分区：
文献类型：
--
作者：
Anna Moles;R. Rizzi;Francesca R. D'Amato
在NMRI小鼠中比较了短暂的母体分离、母体暴露于新的雄性气味和标准饲养的短期和长期影响。第一个条件包括每天15分钟的暴露的幼崽干净的床上用品（CB），和第二个条件包括15分钟的母亲的暴露的气味的陌生男性（SM），从出生后第1天开始出生后14天。因此，这两种情况都需要相同的产妇分离时间。对照母子组不受干扰（未处理，N-H）。在最后一次操作结束时测量母亲和幼崽的皮质酮水平。皮质酮水平较高的SM母亲，从CB和控制母鼠的不同，CB幼崽表现出最高的皮质酮水平与属于其他组的幼崽相比。母亲的行为观察尽可能远离日常分离会议没有不同的三组。在CB和SM动物中，对15日龄幼鼠给予0.5 mg/kg阿扑吗啡的行为反应增强，这表明多巴胺能功能的改变。最后，成年CB和SM雄性小鼠的时间和进入十字迷宫的开放臂的百分比增加相比，nonhandled男性。这项研究表明，暴露于生态相关的刺激引起的应激反应，在哺乳期的母鼠。这种“社会压力”会对后代产生短期和长期的影响，即使在没有对幼崽进行任何直接操纵的情况下。
Short- and long-term effects of brief maternal separation, maternal exposure to novel male odor, and standard rearing were compared in NMRI mice. The first condition consisted of 15 min of daily exposure of pups to clean bedding (CB), and the second condition consisted of 15 min of mothers' exposure to the odor of strange males (SM), for 14 days after birth starting from postnatal Day 1. Thus, both conditions entailed the same period of maternal separation. A control mother-offspring group was left undisturbed (nonhandled, N-H). Corticosterone levels of mothers and pups were measured at the end of the last manipulation session. Corticosterone levels were higher in SM mothers, differing from both those of CB and of control dams; CB pups showed the highest corticosterone levels in comparison with the pups belonging to the other groups. Maternal behavior observed as furthest as possible from the daily separation session did not differ among the three groups. The behavioral response to 0.5 mg/kg of apomorphine in 15-day-old pups was enhanced in both CB and SM animals, which suggests an alteration of dopaminergic functioning. Finally, adult CB and SM male mice showed an increase in the percentage of time and entries into the open arms of the plus-maze in comparison to nonhandled males. This study indicates that exposure to ecologically relevant stimuli elicited a stress response in lactating dams. This "social stress" brings about short- and long-term effects in the offspring, even in the absence of any direct manipulation of the pups.
影响因子：
56.9
作者：
MEANEY, MJ;AITKEN, DH;SAPOLSKY, RM
通讯作者：
SAPOLSKY, RM