Application of a numerical simulation to improve the separation efficiency of a sperm sorter
Application of a numerical simulation to improve the separation efficiency of a sperm sorter
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DOI：
10.1007/s10544-008-9207-2
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发表时间：
2009-02
影响因子：
2.8
通讯作者：
T. Hyakutake;Y. Hashimoto;S. Yanase;K. Matsuura;K. Naruse
中科院分区：
文献类型：
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作者：
T. Hyakutake;Y. Hashimoto;S. Yanase;K. Matsuura;K. Naruse
本文介绍了一项研究，其中数值模拟应用于提高基于微流体的精子分选仪的分离效率。最初，31个精子的运动被建模为正弦波。预期建模的精子在微通道内的流体中振动时移动。在该分析中，获得了在出口通道处提取的精子的数量和高活动性精子在微通道内的宽范围流速下的运动速率。通过改变通道的高度，以及精子入口通道的宽度和位置，我们证实了分离效率高度依赖于通道内的流体速度。这些结果对于改进器件结构具有重要的参考价值，并可能有助于实现未来效率的进一步提高。
This paper describes a study in which numerical simulations were applied to improve the separation efficiency of a microfluidic-based sperm sorter. Initially, the motion of 31 sperm were modeled as a sinusoidal wave. The modeled sperm were expected to move while vibrating in the fluid within the microchannel. In this analysis, the number of sperm extracted at the outlet channel and the rate of movement of the highly motile sperm were obtained for a wide range of flow velocities within the microchannel. By varying the channel height, and the width and the position of the sperm-inlet channel, we confirmed that the separation efficiency was highly dependent on the fluid velocity within the channel. These results will be valuable for improving the device configuration, and might help to realize further improvements in efficiency in the future.