Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation.
Real-time co-localized OCT surveillance of laser therapy using motion corrected speckle decorrelation.
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DOI：
10.1364/boe.385654
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发表时间：
2020-05
影响因子：
3.4
通讯作者：
R. Maltais-Tariant;C. Boudoux;N. Uribe-Patarroyo
中科院分区：
文献类型：
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作者：
R. Maltais-Tariant;C. Boudoux;N. Uribe-Patarroyo
我们提出了一种能够通过双包层光纤（DCF）使用光学相干断层扫描（OCT）成像来实时传输和监测激光治疗的系统。双包层光纤耦合器用于将 OCT 光注入和收集到 DCF 的纤芯中，并将治疗光注入到其较大的内包层中，从而使成像和治疗能够完美配合。通过计算组织凝固期间发生的散斑强度去相关来实现治疗深度的监测。此外，对相关性进行了分析噪声校正，以扩展最大监测深度。我们还提出了一种使用查找表来校正运动引起的去相关的方法。在一种新颖的方法中使用噪声和运动校正相关系数的值，我们的系统能够实时识别热凝固的深度，并在达到目标深度时自动关闭治疗激光。该过程在深度范围为 500 µm 至 1000 µm 的大鼠舌头和腹部肌肉中进行离体演示，并实时诱导运动。
We present a system capable of real-time delivery and monitoring of laser therapy by imaging with optical coherence tomography (OCT) through a double-clad fiber (DCF). A double-clad fiber coupler is used to inject and collect OCT light into the core of a DCF and inject the therapy light into its larger inner cladding, allowing for both imaging and therapy to be perfectly coregistered. Monitoring of treatment depth is achieved by calculating the speckle intensity decorrelation occurring during tissue coagulation. Furthermore, an analytical noise correction was used on the correlation to extend the maximum monitoring depth. We also present a method for correcting motion-induced decorrelation using a lookup table. Using the value of the noise- and motion-corrected correlation coefficient in a novel approach, our system is capable of identifying the depth of thermal coagulation in real time and automatically shut the therapy laser off when the targeted depth is reached. The process is demonstrated ex vivo in rat tongue and abdominal muscles for depths ranging from 500 µm to 1000 µm with induced motion in real time.