Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
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DOI：
10.1093/jn/136.7.1839
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发表时间：
2006-07-01
影响因子：
4.2
通讯作者：
Heber, David
中科院分区：
文献类型：
--
作者：
Henning, Susanne M.;Aronson, William;Heber, David
绿色茶和红茶在前列腺癌的化学预防方面显示出了希望。本研究的目的是测定茶多酚（PP）和茶黄素在人体血清和人体及小鼠组织中的生物利用度和生物活性。向C57 BL/6小鼠施用脱咖啡因红茶饮食。PP和茶黄素在小肠和大肠、肝脏和前列腺中以结合和游离形式被发现。茶黄素的相对前列腺生物利用度比表没食子儿茶素没食子酸酯（EGCG）高70%。在第二项小鼠研究中，给予绿色茶（GT）饮食，然后给予对照饮食1-5天。前列腺组织中的表儿茶素（EC），表没食子儿茶素没食子酸酯（ECG）的浓度显着下降后，1天的消费控制饮食。表没食子儿茶素没食子酸酯（EGC），但是，没有显着减少。在人类研究中，20名计划进行外科乳房切除术的男性被随机分配在根治性乳房切除术前5天每天消耗1.42 L GT，BT或咖啡因匹配的苏打对照（SC）。茶PP是更大的前列腺样本男性消费BT和GT比男性消费SC（P = 0.0025）。虽然茶PP在血清中检测不到，当细胞在含有BT后收集的患者血清的培养基中生长时，离体LNCaP前列腺癌细胞增殖较少（P < 0.001）和GT（P = 0.025）这是第一个人类研究表明，茶多酚和茶黄素在前列腺中是生物可利用的，它们可能在预防前列腺增生中起作用。前列腺癌
Green and black tea have shown promise in the chemoprevention of prostate cancer. The objective of this study was to determine the bioavailability and bioactivity of tea polyphenols (PP) and theaflavins in human serum and human and mouse tissues. A decaffeinated black tea diet was administered to C57BL/6 mice. PPs and theaflavins were found in the small and large intestine, liver, and prostate in conjugated and free forms. The relative prostate bioavailability of theaflavin was 70% higher than that of epigallocatechin gallate (EGCG). In the second mouse study, a green tea (GT) diet was administered followed by the control diet for 1-5 d. Epicatechin (EC), EGCG, and epicatechin gallate (ECG) concentrations in prostate tissue were significantly decreased after 1 d of consuming the control diet. Epigallocatechin gallate (EGC), however, did not decrease significantly. For the human study, 20 men scheduled for surgical prostatectomy were randomly assigned to consume 1.42 L daily of GT, BT, or a caffeine-matched soda control (SC) for 5 d before radical prostatectomy. Tea PPs were greater in prostate samples from men consuming BT and GT than in men consuming SC (P = 0.0025). Although tea PP were not detectable in serum, ex vivo LNCaP prostate cancer cell proliferation was less when cells were grown in media containing patient serum collected after BT (P < 0.001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer.