Development of a fast curing tissue adhesive for meniscus tear repair.
Development of a fast curing tissue adhesive for meniscus tear repair.
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DOI：
10.1007/s10856-016-5790-6
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
Grijpma DW
中科院分区：
文献类型：
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作者：
Bochyńska AI;Hannink G;Janssen D;Buma P;Grijpma DW
异氰酸酯封端的粘合剂两亲性嵌段共聚物由于其可调节的机械性能和良好的粘合特性而成为治疗半月板撕裂的有吸引力的材料。然而，这类材料的缺点是它们的固化时间相对较长。在这项研究中，我们评估使用的胺交联剂和添加催化剂作为两种策略，以加快固化速率的最近开发的可生物降解的反应性异氰酸酯封端的超支化的粘合剂嵌段共聚物制备的聚乙二醇（PEG），三亚甲基碳酸酯，柠檬酸和二异氰酸酯。使用FTIR测定了超支化粘合剂单独的固化动力学和与不同浓度的亚精胺溶液组合的固化动力学，以及在添加2，2-二吗啉基二乙基醚（DMDEE）或1，4-二氮杂双环[2.2.2]辛烷（DABCO）之后的固化动力学。另外，在不同的时间点使用所有组合物进行搭接剪切粘附力测试。在半月板桶柄损伤模型中评价了快速固化粘合剂的两种最有前途的组合物，并将其性能与纤维蛋白胶的性能进行了比较。结果表明，亚精胺和催化剂同时加入到胶粘剂共聚物中，可加快固化速度，2 h后即可达到牢固的粘接。新开发的组合物对半月板组织的粘合强度为3.2- 3.7N，比纤维蛋白胶（0.3N）高得多。所提出的粘合剂组分和交联组分或催化剂的组合是加速异氰酸酯封端的组织粘合剂的固化速率的有希望的方式。
Isocyanate-terminated adhesive amphiphilic block copolymers are attractive materials to treat meniscus tears due to their tuneable mechanical properties and good adhesive characteristics. However, a drawback of this class of materials is their relatively long curing time. In this study, we evaluate the use of an amine cross-linker and addition of catalysts as two strategies to accelerate the curing rates of a recently developed biodegradable reactive isocyanate-terminated hyper-branched adhesive block copolymer prepared from polyethylene glycol (PEG), trimethylene carbonate, citric acid and hexamethylene diisocyanate. The curing kinetics of the hyper-branched adhesive alone and in combination with different concentrations of spermidine solutions, and after addition of 2,2-dimorpholinodiethylether (DMDEE) or 1,4-diazabicyclo [2.2.2] octane (DABCO) were determined using FTIR. Additionally, lap-shear adhesion tests using all compositions at various time points were performed. The two most promising compositions of the fast curing adhesives were evaluated in a meniscus bucket handle lesion model and their performance was compared with that of fibrin glue. The results showed that addition of both spermidine and catalysts to the adhesive copolymer can accelerate the curing rate and that firm adhesion can already be achieved after 2 h. The adhesive strength to meniscus tissue of 3.2–3.7 N was considerably higher for the newly developed compositions than for fibrin glue (0.3 N). The proposed combination of an adhesive component and a cross-linking component or catalyst is a promising way to accelerate curing rates of isocyanate-terminated tissue adhesives.