Predictors of clinical and microbiological treatment failure in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia: a retrospective cohort study in a region with low MRSA prevalence
Predictors of clinical and microbiological treatment failure in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia: a retrospective cohort study in a region with low MRSA prevalence
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DOI：
10.1111/1469-0691.12169
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发表时间：
2013-07-01
影响因子：
14.2
通讯作者：
Burgmann, H.
中科院分区：
文献类型：
--
作者：
Forstner, C.;Dungl, C.;Burgmann, H.
耐甲氧西林金黄色葡萄球菌 (MRSA) 的侵袭性感染与发病率和死亡率增加有关。本研究的目的是确定 MRSA 菌血症患者早期死亡和治疗失败的独立预测因素。对 2000 年至 2011 年间在维也纳大学医院住院期间出现 MRSA 菌血症的 132 名成年患者进行了筛查，其中 124 名患者被纳入一项回顾性队列研究。对患者人口统计、菌血症来源、抗菌治疗和微生物学特征进行了评估。 28天粗死亡率为30.6%。多变量 Cox 回归分析中确定的早期死亡预测因素包括较高的患者年龄（调整后风险比 (aHR) 1.03，95% CI 1.01-1.06，p0.006）、肺炎（aHR 3.86，95% CI 1.83-8.12，p
Invasive infections with methicillin-resistant Staphylococcus aureus (MRSA) have been associated with increased morbidity and mortality. The aim of the present study was to identify independent predictors of early mortality and treatment failure in patients with MRSA bacteraemia. A total of 132 adult patients who developed MRSA bacteraemia during hospitalization in the University Hospital of Vienna between 2000 and 2011 were screened and 124 were included in a retrospective cohort study. Patient demographics, source of bacteraemia, antimicrobial treatment and microbiological characteristics were evaluated. The 28-day crude mortality was 30.6%. Predictors of early mortality identified in multivariate Cox regression analysis included higher patient age (adjusted hazard ratio (aHR) 1.03, 95% CI 1.01-1.06, p0.006), pneumonia (aHR 3.86, 95% CI 1.83-8.12, p