Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women
Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women
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DOI：
10.1016/j.fertnstert.2012.05.042
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发表时间：
2012-09-01
影响因子：
6.7
通讯作者：
Raine-Fenning, Nick
中科院分区：
文献类型：
--
作者：
Jayaprakasan, Kannamannadiar;Chan, YeeYin;Raine-Fenning, Nick
Objective: To estimate the probability of live birth, adverse treatment outcome, and extremes of ovarian response at different antral follicle count (AFC) cutoff levels in a large prospective cohort of women undergoing IVF treatment.Design: Prospective study.Setting: University-based assisted conception unit.Patient(s): A total of 1,012 consecutive subjects of all ages undergoing their first cycle of assisted reproductive techniques.Intervention(s): Transvaginal three-dimensional ultrasound assessment and venipuncture in the early follicular phase of the menstrual cycle.Main Outcome Measure(s): Live birth rate, poor ovarian response, and ovarian hyperstimulation syndrome (OHSS).Result(s): Analysis was performed in 1,012 subjects. Both age (r = 0.88) and AFC (r = 0.92) thresholds show significant linear relationship with the probability of live birth, but AFC demonstrates a stronger correlation. At AFC quartiles of 3-10, 11-15, 16-22, and >= 23, the mean live birth rates were 23%, 34%, 39%, and 44%, respectively. No live birth was observed in women with AFC < 4. Antral follicle count was predictive of ovarian response, with a 67% likelihood of poor ovarian response for AFC
