Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials
Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials
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DOI：
10.1002/mnfr.200800076
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发表时间：
2009-08-01
影响因子：
5.2
通讯作者：
Lhuguenot, Jean-Claude
中科院分区：
文献类型：
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作者：
Lhuguenot, Jean-Claude
在20世纪80年代和90年代，在欧盟层面，食品科学委员会评估了一些正在使用或要求使用的邻苯二甲酸酯作为塑料添加剂。此时，过氧化物酶体增殖被认为是这些化学品毒理学评价的关键作用。在20世纪90年代末，人们普遍认为啮齿类动物对过氧化物酶体增殖现象高度敏感，这种特殊效应不应用于人类风险评估。因此，在2004年，新成立的欧洲食品安全局要求根据现有数据对主要使用的邻苯二甲酸酯进行新的评估。本文综述了邻苯二甲酸丁基苄酯、邻苯二甲酸二丁酯、邻苯二甲酸二乙基己酯的评价方法。
During the 1980s and 1990s, and at the EU level, the Scientific Committee for Food evaluated a number of phthalates that were being used, or were requested for use, as additives in plastics. At this time, peroxisome proliferation was considered as the pivotal effect oil which toxicological evaluation of these chemicals was based. At the end of 1990s, a general consensus has been agreed that rodents are highly sensitive to the phenomenon of peroxisome proliferation and that this particular effect Should not be used for human risk assessment. Consequently in 2004, it was requested from the newly created European Food Safety Authority to perforin a new evaluation of the mainly used phthalates on the basis of existing data. This paper smmarizes evaluations of butylbenzylphthalate, dibutylphthalate, diethylhexylphthalate.