Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries
Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income Countries
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DOI：
10.1093/cid/cix879
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发表时间：
2018-03-15
影响因子：
11.8
通讯作者：
Guillemot, Didier
中科院分区：
文献类型：
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作者：
Nadimpalli, Maya;Delarocque-Astagneau, Elisabeth;Guillemot, Didier
为了解决全球抗生素耐药性危机，低收入和中等收入国家越来越需要“一个健康”的观点。在这里，我们描述了考虑到集约化生产的肉类和鱼类中越来越多的抗生素使用、糟糕的食品安全和普遍的环境污染的战略。中低收入国家(LMIC)的抗生素滥用有助于抗生素耐药性的发展，并可在全球范围内传播。已经提出了针对LMICs的战略，这些战略寻求减少人类滥用抗生素，但同时改善抗生素的获得。然而，到目前为止，大多数方法都没有考虑到抗生素耐药性的动物和环境宿主的日益增长的影响，这可能会加剧LMICs中的抗生素耐药性危机。特别是，目前的战略没有优先考虑增加抗生素使用对陆地食用动物和水产养殖生产、不充分的食品安全和普遍的环境污染的影响。在这里，我们提出了应对新出现的一个卫生挑战的新方法。
To address the global antibiotic resistance crisis, a One Health perspective is increasingly needed in lower- and middle-income countries. Here, we describe strategies that consider growing antibiotic use among intensively produced meat and fish, poor food safety, and widespread environmental pollution.Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific to LMICs that seek to reduce antibiotic misuse by humans, but simultaneously improve antibiotic access, have been proposed. However, most approaches to date have not considered the growing impact of animal and environmental reservoirs of antibiotic resistance, which threaten to exacerbate the antibiotic resistance crisis in LMICs. In particular, current strategies do not prioritize the impacts of increased antibiotic use for terrestrial food-animal and aquaculture production, inadequate food safety, and widespread environmental pollution. Here, we propose new approaches that address emerging, One Health challenges.