A NEW ONE-TRIAL TEST FOR NEUROBIOLOGICAL STUDIES OF MEMORY IN RATS .1. BEHAVIORAL-DATA
A NEW ONE-TRIAL TEST FOR NEUROBIOLOGICAL STUDIES OF MEMORY IN RATS .1. BEHAVIORAL-DATA
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DOI：
10.1016/0166-4328(88)90157-x
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发表时间：
1988-11-01
影响因子：
2.7
通讯作者：
DELACOUR, J
中科院分区：
文献类型：
--
作者：
ENNACEUR, A;DELACOUR, J
在本文中，我们描述了一种新的大鼠记忆测试，该测试基于对熟悉的和新的对象的差异探索。在第一个试验(T1)中，大鼠暴露在一个或两个相同的对象(样本)中，在第二个试验中，暴露于两个不同的对象，一个熟悉的(样本)和一个新的。对于较短的试验间隔(.apprxeq.1分钟)，大多数老鼠在T2中区分这两个物体：它们花在探索新物体上的时间比探索熟悉的物体更多。这项测试有几个有趣的特点：(1)它类似于在亚人类灵长类动物中广泛使用的视觉识别测试，这允许进行物种间比较；(2)它完全基于大鼠的自发行为，可以被认为是一种完全没有参考记忆成分的“纯”工作记忆测试；(3)它不涉及初级强化，如食物或电击，这使其可与目前在人类上使用的记忆测试相媲美。
In this paper we describe a new memory test in rats, based on the differential exploration of familiar and new objects. In a first trial (T1), rats are exposed to one or to two identical objects (samples) and in a second trial, to two dissimilar objects, a familiar (the sample) and a new one. For short intertrial intervals (.apprxeq. 1 min), most rats discriminate between the two objects in T2: they spend more time in exploring the new object than the familiar one. This test has several interesting characteristics: (1) it is similar to visual recognition tests widely used in subhuman primates, this allows interspecies comparisons; (2) it is entirely based on the spontaneous behavior of rats and can be considered as a ''pure'' working-memory test completely free of reference memory component; (3) it does not involve primary reinforcement such as food or electric shocks, this makes it comparable to memory tests currently used in man.