Engineering a microcirculation for perfusion control of ex vivo-assembled organ systems: Challenges and opportunities.
Engineering a microcirculation for perfusion control of ex vivo-assembled organ systems: Challenges and opportunities.
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DOI：
10.1177/2041731418772949
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发表时间：
2018-01
影响因子：
8.2
通讯作者：
Herman I
中科院分区：
文献类型：
--
作者：
Kottamasu P;Herman I
捐献器官短缺仍然是世界各地许多终末期器官患者面临的一个明显问题。与需要这些器官的病人数量相比，可用的捐赠器官数量相形见绌。组织工程学领域提出了一个合理的解决方案。使用干细胞，患者的自体细胞或同种异体移植细胞来种子工程支架，组织工程构建体可以有效地补充供体库并绕过使用供体器官时出现的其他问题，例如谁首先接受器官以及是否可能发生供体器官排斥。然而，目前的研究方法和技术还不能成功地工程化和血管化大体积组织构建体。本文综述了目前离体器官系统的灌注方法，定义了不同类型的血管化器官，探讨了各种策略，血管化离体器官系统，并讨论了组织工程领域的挑战和机遇。
Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient’s autologous cells, or allografted cells to seed-engineered scaffolds, tissue-engineered constructs can effectively supplement the donor pool and bypass other problems that arise when using donor organs, such as who receives the organ first and whether donor organ rejection may occur. However, current research methods and technologies have been unable to successfully engineer and vascularize large volume tissue constructs. This review examines the current perfusion methods for ex vivo organ systems, defines the different types of vascularization in organs, explores various strategies to vascularize ex vivo organ systems, and discusses challenges and opportunities for the field of tissue engineering.
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影响因子：
0.9
作者：
Afonso, R. C.;Hidalgo, R.;Ferraz-Neto, B. H.
通讯作者：
Ferraz-Neto, B. H.
影响因子：
7.4
作者：
Douville, Nicholas J.;Tung, Yi-Chung;Li, Ran;Wang, Jack D.;El-Sayed, Mohamed E. H.;Takayama, Shuichi
通讯作者：
Takayama, Shuichi
DOI：
10.1073/pnas.94.16.8761
发表时间：
1997-08-05
影响因子：
11.1
作者：
Benjamin, LE;Keshet, E
通讯作者：
Keshet, E
影响因子：
--
作者：
Atterbury, RR
通讯作者：
Atterbury, RR
DOI：
10.1016/0007-1226(93)90172-8
发表时间：
1993-04-01
期刊：
BRITISH JOURNAL OF PLASTIC SURGERY
影响因子：
--
作者：
COSTA, H;CUNHA, C;LOPES, A
通讯作者：
LOPES, A