Evolutionary capacitance may be favored by natural selection
Evolutionary capacitance may be favored by natural selection
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DOI：
10.1534/genetics.105.040493
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发表时间：
2005-07-01
期刊：
影响因子：
3.3
通讯作者：
Masel, J
中科院分区：
文献类型：
--
作者：
Masel, J
进化电容器的表型揭示了一个股票的神秘的遗传变异的可逆方式。一系列变异的突然而可逆的显露，与通过突变逐渐引入变异是根本不同的。在这里，我研究了启示修饰语的入侵动力学。具有最佳启示率的修改器，入侵其他种群的概率比被反入侵的概率高。m（opt）随人口规模N和环境变化使启示适应的速率0而变化。对于小于最小截止值N-min的小群体，选择所有启示。N-min通常非常小，并且随着θ（-1/2）仅微弱地增加。对于N > 1/theta的大种群，m（opt）与1/N相似。选择最优值是非常有效的，并且随着N >> 1/0的增大而有效性增加。对于N的中间值，m（opt）通常略小于0，并且仅弱于较不频繁的揭示。该模型是类似于一个两个基因座的突变等位基因的进化模型。这是一个完全随机的模型，因此能够表明，对启示的选择可以强大到足以克服随机漂移。
Evolutionary capacitors phenotypically reveal a stock of cryptic genetic variation in a reversible fashion. The sudden and reversible revelation of a range of variation is fundamentally different from the gradual introduction of variation by mutation. Here I study the invasion dynamics of modifiers of revelation. A modifier with the optimal rate of revelation in., has a higher probability of invading any other population than of being counterinvaded. m(opt) varies with the population size Nand the rate 0 at which environmental change makes revelation adaptive. For small populations less than a minimum cutoff N-min all revelation is selected against. N-min is typically quite small and increases only weakly, with theta(-1/2). For large populations with N > 1/theta, m(opt), is similar to 1/N. Selection for the optimum is highly effective and increases in effectiveness with larger N >> 1/0. For intermediate values of N, m(opt) is typically a little less than 0 and is only weakly favored over less frequent revelation. The model is analogous to a two-locus model for the evolution of a mutator allele. It is a fully stochastic model and so is able to show that selection for revelation can be strong enough to overcome random drift.