Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study.
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study.
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在中国，遵守中国或美国膳食指南与降低原发性肝癌风险相关：病例对照研究
DOI：
10.3390/nu10081113
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发表时间：
2018-08-17
期刊：
影响因子：
5.9
通讯作者：
Zhu HL
中科院分区：
文献类型：
--
作者：
Chen PY;Fang AP;Wang XY;Lan QY;Liao GC;Liu ZY;Zhang DM;Zhang YY;Chen YM;Zhu HL
遵守健康饮食指南与降低多种癌症的风险有关，但其在原发性肝癌 (PLC) 中的作用尚未得到充分研究，特别是在东方人群中。本研究招募了 2013 年 9 月至 2017 年 10 月期间在华南地区按年龄和性别进行频率匹配的 720 名 PLC 患者和 720 名健康对照者。膳食质量通过中国健康饮食指数（CHEI）和2015年健康饮食指数（HEI-2015）进行评估，分别表现为遵守2016年中国膳食指南和遵守2015-2020年美国人膳食指南的得分。使用无条件逻辑回归模型估计优势比 (OR) 和 95% 置信区间 (CI)，并调整潜在的混杂因素。 CHEI 和 HEI-2015 得分越高，患 PLC 的风险越低（总分每增加 5 分：CHEI 的 OR：0.43，95% CI：0.38–0.50；HEI-2015 的 OR：0.47，95% CI：0.40–0.55）。在按性别、吸烟状况、饮酒、HBV 感染和 PLC 组织学类型进行的分层分析中，保护性关联显着存在，但没有异质性的统计证据（p 交互作用 > 0.05）。严格遵守中国或美国人的最新饮食指南可能会预防 PLC。
Adherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by age and sex between September 2013 and October 2017 in South China. Dietary quality was assessed by the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI-2015), which manifests as scores of adhering to the 2016 Dietary Guidelines for Chinese and adhering to the 2015–2020 Dietary Guidelines for Americans, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models, adjusting for potential confounders. Higher scores in both the CHEI and HEI-2015 were associated with a lower risk of PLC (per 5-points increment of the total scores: OR: 0.43, 95% CI: 0.38–0.50 for CHEI; OR: 0.47, 95% CI: 0.40–0.55 for HEI-2015). The protective associations persisted significantly in the stratified analyses by sex, smoker status, alcohol consumption, HBV infection, and histological types of PLC, without statistical evidence for heterogeneity (p-interaction > 0.05). Closer adherence to the most recent dietary guidelines for Chinese or Americans may protect against PLC.