Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
Endoplasmic reticulum: one continuous network compartmentalized by extrinsic cues
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DOI：
10.1016/j.ceb.2005.06.005
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发表时间：
2005-08-01
影响因子：
7.5
通讯作者：
Rabouille, C
中科院分区：
文献类型：
--
作者：
Levine, T;Rabouille, C
内质网（ER）是一个广泛的三维网络，从内核被膜延伸到细胞皮质，具有单一连续的膜和单一连续的管腔。然而，ER包含执行独特功能的专门区域。立即出现的问题是，如果ER是连续的，它如何被划分，对此的答案是，具有独特亚细胞分布的细胞标志从外部对ER施加不均匀性，从而产生ER的结构和功能子域。
The endoplasmic reticulum (ER) is an extensive three-dimensional network that stretches from the inner nuclear envelope to the cell cortex with a single, continuous membrane and a single, continuous lumen. Yet the ER contains specialized regions that carry out unique functions. The question that immediately arises is how the ER can be compartmentalized if it is continuous, and the answer to this is that cellular landmarks with unique sub-cellular distributions impose non-uniformity on the ER from outside, creating structural and functional sub-domains of the ER.