Sexual Dysfunctions and Suicidality in Patients with Bipolar Disorder and Unipolar Depression
Sexual Dysfunctions and Suicidality in Patients with Bipolar Disorder and Unipolar Depression
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DOI：
10.1111/j.1743-6109.2009.01455.x
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发表时间：
2009-11-01
影响因子：
3.5
通讯作者：
Maggi, Mario
中科院分区：
文献类型：
--
作者：
Dell'Osso, Liliana;Carmassi, Claudia;Maggi, Mario
简介：精神障碍患者，尤其是情绪障碍患者，性功能受损很常见，但被低估了。很少有研究探讨性功能障碍与情绪障碍临床特征之间的关系。目的。本研究的目的是探讨相对于对照受试者，双相 I 型障碍 (BD) 和单相抑郁 (UD) 患者性功能障碍的频率，以及它们与自杀倾向的关系。主要结果指标。评估包括：精神障碍诊断和统计手册第四版结构化临床访谈 (SCID-I/P)、 24 项简短精神病评定量表和情绪谱自我报告，这是一份探索一生情绪谱症状学的调查问卷，包括性功能和自杀症状。方法。在一项涉及 11 个精神病学学术部门的多中心研究中，招募了 142 名患者（60 名 BD 和 82 名 UD）的连续样本和 101 名对照受试者的对照组。结果。性反应周期中的终生损害，包括欲望、与对照组相比，情绪障碍患者的兴奋和达到性高潮的能力明显更常见。与其他两组相比，双相障碍患者的性活动增加和乱交明显更为常见。所研究的性反应周期所有三个阶段的终生功能障碍与双相障碍患者的终生自杀未遂以及与UD患者的死亡想法显着相关。在 BD 患者中，一生中频繁更换性伴侣的时期与死亡想法显着相关。结论。我们的研究结果表明评估 BD 或 UD 患者性功能障碍的重要性，因为它们可能在临床上有助于识别以高自杀性为特征的情绪障碍表型。 Dell'Osso L、Carmassi C、Carlini M、Rucci P、Torri P、Cesari D、Landi P、Ciapparelli A 和 Maggi M。双相情感障碍和单相抑郁患者的性功能障碍和自杀倾向。 《性医学杂志》2009 年；6：3063-3070。
Introduction.Impairment in sexual function is frequent and underestimated in patients with mental disorders, particularly in those with mood disorders. Few studies have examined the relationship between sexual dysfunctions and the clinical characteristics of mood disorders.Aim.The aim of the present study was to explore the frequency of sexual dysfunctions in patients with bipolar I disorder (BD) and unipolar depression (UD) with respect to control subjects, as well as their relationship with suicidality.Main Outcome Measures.Assessments included: the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (SCID-I/P), the 24-item Brief Psychiatric Rating Scale and the Mood Spectrum Self-Report, a questionnaire exploring lifetime mood spectrum symptomatology including symptoms of sexual functioning and suicidality.Methods.A consecutive sample of 142 patients (60 BD and 82 UD) and a comparison group of 101 control subjects were recruited in a multicenter study involving 11 academic departments of psychiatry.Results.Lifetime impairment in the sexual response cycle, including desire, excitement, and ability to achieve orgasm, was significantly more common in patients with mood disorders compared with control subjects. Increase in sexual activity and promiscuity were significantly more common in patients with BD vs. the other two groups.Lifetime dysfunctions in all three phases of the sexual response cycle explored were significantly associated with lifetime suicide attempts in patients with BD and with thoughts of death in patients with UD. In BD patients, the lifetime presence of periods with frequent changes of sexual partners was significantly associated with thoughts of death.Conclusions.Our findings suggest the importance of assessing sexual dysfunctions in patients with either BD or UD, as they may be clinically helpful in identifying phenotypes of mood disorders characterized by high suicidality. Dell'Osso L, Carmassi C, Carlini M, Rucci P, Torri P, Cesari D, Landi P, Ciapparelli A, and Maggi M. Sexual dysfunctions and suicidality in patients with bipolar disorder and unipolar depression. J Sex Med 2009;6:3063-3070.