Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts
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DOI：
10.1016/j.canlet.2005.10.003
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发表时间：
2006-09-08
期刊：
影响因子：
9.7
通讯作者：
Masutani, Mitsuko
中科院分区：
文献类型：
--
作者：
Gunji, Akemi;Uemura, Akiko;Masutani, Mitsuko
在ICR/129Sv混合遗传背景的小鼠中，研究了聚腺苷二磷酸核糖聚合酶-1(PARP-1)缺失对4-硝基喹啉-1-氧化物(4NQO)致癌作用的影响。PARP-1(+/+)、PARP-1(+/-)和PARP-I-/-动物在饮水中以0.001%的比例摄入4NQO，可发生舌头乳头状瘤和鳞状细胞癌，但与PARP-1基因无显著差异。因此，PARP-1缺乏并不会增加致癌物致癌的易感性，致癌物会导致巨大的DNA损伤。本研究还表明ICR/129Sv混合遗传背景与4NQO诱导食道肿瘤的高产有关。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
The impact of poly(ADP-ribose) polymerase-1 (Parp-1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1(+/+), Parp-1(+/-) and Parp-I-/- animals given 4NQO for thirty-two weeks at 0.001% in their drinking water developed papillomas and squamous cell carcinomas of the tongue, palate and esophagus, but with no statistically significant variation with the Parp-1 genotype. Thus Parp-1 deficiency does not elevate susceptibility to carcinogenesis induced by a carcinogen which gives rise to bulky DNA lesions. This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO. (c) 2006 Elsevier Ireland Ltd. All rights reserved.