Evaluation of the effect of myocardial segmentation errors on myocardial blood flow estimates from DCE-MRI
Evaluation of the effect of myocardial segmentation errors on myocardial blood flow estimates from DCE-MRI
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DOI：
10.1088/0031-9155/56/8/007
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发表时间：
2011-04-21
影响因子：
3.5
通讯作者：
Radjenovic, A.
中科院分区：
文献类型：
--
作者：
Biglands, J.;Magee, D.;Radjenovic, A.
心脏动态对比增强磁共振成像（DCE-MRI）灌注数据集的定量分析依赖于心肌轮廓的绘制（手动或自动）。这些轮廓心肌血流量（MBF）估计所需的准确性还没有得到很好的理解。本研究探讨心肌轮廓误差与MBF误差之间的关系。在心脏收缩期成像的健康志愿者的DCE-MRI灌注数据集上手动绘制心肌轮廓。用样条曲线模拟了系统和随机轮廓误差，并计算了MBF中的误差。轮廓误差的程度也进行了评估，由两个公认的分割指标。我们推导出轮廓误差容限的最大偏差（MD）的轮廓可以径向偏离的“真实”的轮廓表示为每个志愿者的平均心肌宽度（MW）的一部分。通过设置MD的公差，避免了显著的MBF误差
Quantitative analysis of cardiac dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) perfusion datasets is dependent on the drawing (manually or automatically) of myocardial contours. The required accuracy of these contours for myocardial blood flow (MBF) estimation is not well understood. This study investigates the relationship between myocardial contour errors and MBF errors. Myocardial contours were manually drawn on DCE-MRI perfusion datasets of healthy volunteers imaged in systole. Systematic and random contour errors were simulated using spline curves and the resulting errors in MBF were calculated. The degree of contour error was also evaluated by two recognized segmentation metrics. We derived contour error tolerances in terms of the maximum deviation (MD) a contour could deviate radially from the 'true' contour expressed as a fraction of each volunteer's mean myocardial width (MW). Significant MBF errors were avoided by setting tolerances of MD