Identification and Regulation of β-Adrenergic Receptors
Identification and Regulation of β-Adrenergic Receptors
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β-肾上腺素能受体的识别和调节
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
R. Lefkowitz
中科院分区：
文献类型：
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作者：
R. Lefkowitz
一段时间以来，受体的概念一直被用来解释激素和药物对组织作用的显著特异性。然而，只是在过去的几年里，一个直接的实验方法来研究这些细胞结构已经成为可能。自1970年以来，放射性标记的激素和药物越来越多地被用于直接鉴定多肽激素和神经递质的各种受体。相比之下，各种技术问题阻碍了直接鉴定膜结合的肾上腺素能受体的儿茶酚胺。最近，这些技术问题已被克服（Lefkowitz，1975）。
The receptor concept has been used for some time to explain the striking specificity of hormone and drug effects on tissues. However, it is only within the past few years that a direct experimental approach to the study of these cellular structures has become possible. Since about 1970 radioactively-labeled hormones and drugs have been used with increasing frequency for the purpose of direct identification of a wide variety of receptors for polypeptide hormones and neurotransmitters. By contrast, a variety of technical problems have hindered such direct identification of the membrane-bound adrenergic receptors for catecholamines. Quite recently, these technical problems have been overcome (Lefkowitz, 1975).