Long-term drift and continued efficacy after multiyear timolol therapy.
Long-term drift and continued efficacy after multiyear timolol therapy.
复制标题
多年噻吗洛尔治疗后的长期漂移和持续疗效。
DOI：
10.1001/archopht.1981.03930010102012
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发表时间：
1981
影响因子：
--
通讯作者：
W. P. Boger
中科院分区：
文献类型：
--
作者：
R. Steinert;J. V. Thomas;W. P. Boger
本文回顾了41例接受马来酸替马洛尔治疗的患者的临床过程。我们重新评估了17例原发性开角型青光眼患者血压升高的情况，这些患者单独或联合其他青光眼药物治疗最多35个月（平均26个月）。停用替莫洛尔导致平均眼压升高5mmhg。8例单独使用替莫洛尔的患者在随访期间眼压出现进行性、显著性升高3mmhg或“长期漂移”。然而，替莫洛尔停药后的血压升高并不明显低于替莫洛尔开始时的血压降低。替马洛尔停药后，至少需要两周时间才能“洗脱”或消失，再治疗一周后IOP恢复到停药前水平。
The clinical courses of 41 patients who received timolol maleate for experimental protocols were reviewed. We reevaluated the conditions of 17 patients with the elevated pressures of primary open angle glaucoma who had received timolol alone or in combination with other glaucoma medications for a maximum of 35 months (average, 26 months). Withdrawal of timolol led to an average intraocular pressure rise of 5 mm Hg. Eight patients treated with timolol alone showed a progressive, significant, 3-mm Hg upward rise, or "long-term drift" in IOP during the follow-up period. Pressure rise after timolol withdrawal, however, was not significantly less than pressure reduction when timolol was initiated. At least two weeks are required for "washout" or disappearance of timolol effect after timolol is withdrawn, and re-treatment for one week restores IOP to prewithdrawal levels.