Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
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DOI：
10.3109/08830189409051176
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发表时间：
1994-01-01
影响因子：
5
通讯作者：
Mak, T W
中科院分区：
文献类型：
--
作者：
Ferrick, D A;Gemmell-Hori, L;Mak, T W
免疫耐受是抑制或消除识别自身来源抗原的淋巴细胞的过程。通过去除潜在有害的自反应性克隆，这种机制允许随机产生多种多样的t细胞库，能够对外来病原体做出反应。虽然所有的自反应性t细胞都应该从库中移除，但从最近的许多研究中可以清楚地看出，在正常健康小鼠中，携带γ δ t细胞受体（TCR）的t细胞中有很大一部分识别自源抗原。健康动物中自身反应性t细胞的存在提出了一个悖论，这可以通过理解抗原（例如，MHC类Ib，热休克蛋白）的瞬时表达来解释，这些抗原迄今已被鉴定为γ δ t细胞。本文将对V γ - 1.1C - γ - 4转基因小鼠的实验数据进行综述，这些数据表明存在自反应性γ δ t细胞及其对淋巴细胞发育和免疫监视的影响。
Immunological tolerance is the process of inhibiting or eliminating lymphocytes that recognize self-derived antigens. By removing potentially harmful self-reactive clones, this mechanism allows for the random generation of a diverse repertoire of T-cells capable of responding to foreign pathogens. Although all self-reactive T-cells should be removed from the repertoire, it is quite clear from many recent studies that a significant fraction of T-cells bearing gamma delta T-cell receptors (TCR) recognize self-derived antigens in normal healthy mice. The presence of self-reactive T-cells in healthy animals presents a paradox which may be explained by understanding the transient expression of the antigens (e.g., MHC class Ib, Heat Shock Proteins) that have been identified for gamma delta T-cells thus far. Data from experiments with V gamma 1.1C gamma 4 transgenic mice demonstrating the presence of self-reactive gamma delta T-cells and their influence on lymphoid development and immune surveillance will be examined in this review.