Host-pathogen interactions: The role of iron
Host-pathogen interactions: The role of iron
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DOI：
10.1093/jn/137.5.1341
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发表时间：
2007-05-01
影响因子：
4.2
通讯作者：
Doherty, Conor P.
中科院分区：
文献类型：
--
作者：
Doherty, Conor P.
铁对宿主和病原体都是必不可少的，复杂的获取和利用系统在竞争中进化。我们对体内平衡的基本机制及其在缺乏、过载和感染期间的适应性的认识越来越多，表明铁是宿主病原体相互作用的关键调节剂。本综述集中在临床和公共卫生方面的铁收购机制之间的相互作用的选择病原体的公共卫生重要性与宿主铁稳态。这些相互作用的知识是必不可少的，在评估可能的发病率补充反应。
Iron is essential for both host and pathogen, and complex systems of acquisition and utilization have evolved in competition. Our increasing knowledge of the basic mechanisms of homeostasis and their adaptation during deficiency, overload, and infection indicate that iron is a key regulator of host pathogen interactions. This review concentrated on the clinical and public health aspects of the interaction between the iron acquisition mechanisms of select pathogens of public health importance with host iron homeostasis. Knowledge of these interactions is essential in assessing likely morbidity responses to supplementation.