Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway.
Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway.
复制标题
年龄相关性白内障的氧化还原调节：谷胱甘肽、维生素C和NRF2信号通路的作用。
作者：
年龄是白内障的最大危险因素，异常氧化修饰与年龄相关性白内障相关，表明适当的氧化还原调节对透镜清晰度很重要。透镜具有非常高水平的抗氧化剂，包括抗坏血酸盐和谷胱甘肽，其有助于保持透镜透明，至少在年轻动物和人类中是如此。我们总结了目前的功能和遗传数据支持的假设，即受损的氧化应激调节导致氧化还原失调和白内障。我们将集中在必要的内源性抗氧化剂谷胱甘肽和外源性抗氧化剂维生素C/抗坏血酸。此外，对氧化应激反应的基因表达部分受转录因子NRF 2（核因子红细胞2相关因子2 [NFE 2L 2]）调节，因此我们将总结我们关于Nrf 2-/-小鼠白内障的数据。在这项工作中，我们讨论的功能和整合这些能力的目标，保持透镜清晰度。
Age is the biggest risk factor for cataracts, and aberrant oxidative modifications are correlated with age-related cataracts, suggesting that proper redox regulation is important for lens clarity. The lens has very high levels of antioxidants, including ascorbate and glutathione that aid in keeping the lens clear, at least in young animals and humans. We summarize current functional and genetic data supporting the hypothesis that impaired regulation of oxidative stress leads to redox dysregulation and cataract. We will focus on the essential endogenous antioxidant glutathione and the exogenous antioxidant vitamin C/ascorbate. Additionally, gene expression in response to oxidative stress is regulated in part by the transcription factor NRF2 (nuclear factor erythroid 2-related factor 2 [NFE2L2]), thus we will summarize our data regarding cataracts in Nrf2-/- mice. In this work, we discuss the function and integration of these capacities with the objective of maintaining lens clarity.
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