High Plasma Brain Natriuretic Peptide Levels in Stable COPD without Pulmonary Hypertension or Cor Pulmonale
High Plasma Brain Natriuretic Peptide Levels in Stable COPD without Pulmonary Hypertension or Cor Pulmonale
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DOI：
10.2169/internalmedicine.48.1701
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Aizawa, Hisamichi
中科院分区：
文献类型：
--
作者：
Inoue, Yuzuru;Kawayama, Tomotaka;Aizawa, Hisamichi
背景慢性阻塞性肺疾病（COPD）合并肺动脉高压（PH）和肺心病患者预后差，早期诊断尤为重要。目的探讨脑钠肽（BNP）对COPD的诊断价值。方法测定60例无PH或肺心病症状或体征的COPD患者血浆BNP水平10名哮喘患者和30名健康受试者。还进行了超声心动图、动脉血气分析和肺功能测定。在3年的随访期内，比较了血浆BNP水平较高和较低的COPD患者的死亡率和病情恶化情况。结果COPD患者的血浆BNP（平均值+/- SEM，pg/mL）（41.0 +/- 6.6）明显高于正常人（14.8 +/- 2.7）和哮喘患者（17.4 +/- 4.5）（p
Background Early diagnosis of chronic obstructive pulmonary disease (COPD) with latent pulmonary hypertension (PH) and cor pulmonale is important because the prognosis of this condition is poor.Objective To investigate the utility of brain natriuretic peptide (BNP) for prognostication of COPD, plasma BNP was measured in patients with COPD without symptoms or physical findings of PH or cor pulmonale.Methods Plasma BNP was measured in 60 patients with COPD, 10 asthmatics, and 30 healthy subjects. Echocardiography, arterial blood gas analysis, and spirometry were also performed. Mortality and exacerbation were compared between COPD patients with high and low plasma BNP levels over a 3-year follow-up period.Results Plasma BNP (mean +/- SEM, pg/mL) in COPD patients (41.0 +/- 6.6) was significantly higher than in normal subjects (14.8 +/- 2.7) and asthmatics (17.4 +/- 4.5) (p