TrkA expression in mouse olfactory tract following axotomy of olfactory nerves.
TrkA expression in mouse olfactory tract following axotomy of olfactory nerves.
复制标题
嗅神经轴切术后小鼠嗅道中 TrkA 的表达。
DOI：
10.1080/00016489850182198
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
T. Moriizumi
中科院分区：
文献类型：
--
作者：
T. Miwa;I. Horikawa;N. Uramoto;T. Ishimaru;K. Yamamoto;M. Furukawa;T. Kato;T. Moriizumi
嗅球是合成神经生长因子（NGF）的大脑区域之一。延髓神经生长因子的功能仍有待确定。本研究的目的是，使用高亲和力NGF受体（trkA）特异性抗体，用免疫组织化学方法检测正常条件下和再生过程中小鼠嗅觉道中NGF受体的分布。在正常小鼠嗅上皮中，trkA免疫反应阳性细胞体仅见于基底细胞。嗅觉受体细胞的胞体不表达trkA免疫反应性，但其神经突起（嗅粘膜和嗅球中的嗅觉神经纤维和束）显示trkA免疫反应性。嗅神经切断后，再生的嗅细胞（基底细胞和嗅感受器细胞）在嗅感受器细胞的粘膜内和球内神经突起表达trkA免疫反应性。这些结果表明，参与延髓神经生长因子的过程中的突触和/或再生的嗅觉神经系统。
The olfactory bulb is one of the brain regions that synthesizes the nerve growth factor (NGF). Functional roles of the bulbar NGF remain to be determined. The aim of the present study was, using an antibody specific to the high-affinity NGF receptor (trkA), to examine immunohistochemically the distribution of the NGF receptor in the mouse olfactory tract, under normal conditions and during regenerative processes. In normal mouse olfactory epithelia, trkA immunoreactive cell bodies were only seen in basal cells. Cell bodies of olfactory receptor cells did not express trkA immunoreactivity, but their neuronal processes (olfactory nerve fibres and bundles in the olfactory mucosa and the olfactory bulb) displayed trkA immunoreactivity. After axotomy of olfactory nerves, regenerating olfactory cells (basal cells and olfactory receptor cells) expressed trkA immunoreactivity in intramucosal and intrabulbar neuronal processes of olfactory receptor cells. These results suggest involvement of the bulbar NGF in the process of synaptogenesis and/or regeneration of the olfactory nervous system.