Air pollution-associated changes in lung function among asthmatic children in Detroit.
Air pollution-associated changes in lung function among asthmatic children in Detroit.
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DOI：
10.1289/ehp.7533
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发表时间：
2005-08
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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在一项对密歇根州底特律市小学年龄哮喘儿童的纵向队列研究中，我们使用广义估计方程，在不同的滞后时间间隔内检查了肺功能与直径≤ 10 μm和≤ 2.5 μm的颗粒物（PM10和PM2.5）和臭氧的环境水平之间的关系。模型认为效果修改的维持皮质类固醇（CS）的使用和上呼吸道感染（URI）的存在下，记录在每日日记中的86名儿童参加了6个2周的季节性评估，从2001年冬季至2002年春季。参与者主要是来自低收入家庭的非洲裔美国人，> 75%被归类为患有持续性哮喘。在单污染物和双污染物模型中，许多回归分析表明，在使用CSs的儿童中，环境污染物暴露量较高与肺功能较差（昼夜变异性增加，1秒用力呼气量每日最低值降低）之间存在关联，但在未使用CSs的儿童中，以及报告URI症状的儿童中，但在未报告URI的儿童中，两者之间没有关联。我们的研究结果表明，底特律的空气污染物水平高于现行的国家环境空气质量标准，对易感哮喘儿童的肺功能产生不利影响。
In a longitudinal cohort study of primary-school–age children with asthma in Detroit, Michigan, we examined relationships between lung function and ambient levels of particulate matter ≤ 10 μm and ≤ 2.5 μm in diameter (PM10 and PM2.5) and ozone at varying lag intervals using generalized estimating equations. Models considered effect modification by maintenance corticosteroid (CS) use and by the presence of an upper respiratory infection (URI) as recorded in a daily diary among 86 children who participated in six 2-week seasonal assessments from winter 2001 through spring 2002. Participants were predominantly African American from families with low income, and > 75% were categorized as having persistent asthma. In both single-pollutant and two-pollutant models, many regressions demonstrated associations between higher exposure to ambient pollutants and poorer lung function (increased diurnal variability and decreased lowest daily values for forced expiratory volume in 1 sec) among children using CSs but not among those not using CSs, and among children reporting URI symptoms but not among those who did not report URIs. Our findings suggest that levels of air pollutants in Detroit, which are above the current National Ambient Air Quality Standards, adversely affect lung function of susceptible asthmatic children.