ARTIFACTUAL CHANGES MIMICKING SIGNET RING CELL-CARCINOMA IN TRANSURETHRAL PROSTATECTOMY SPECIMENS
ARTIFACTUAL CHANGES MIMICKING SIGNET RING CELL-CARCINOMA IN TRANSURETHRAL PROSTATECTOMY SPECIMENS
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DOI：
10.1097/00000478-198611000-00007
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发表时间：
1986-11-01
影响因子：
5.6
通讯作者：
ALGUACILGARCIA, A
中科院分区：
文献类型：
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作者：
ALGUACILGARCIA, A
对20例经尿道前列腺切除术（TURP）的组织学研究显示，除1例外，所有病例间质中均可见印戒细胞聚集。它们通常与致密的淋巴细胞浸润有关，但偶尔也会浸润纤维肌间质并类似于癌。粘蛋白和免疫反应的前列腺特异性酸性磷酸酶（PSAP）和前列腺特异性抗原（PSA）和局灶性阳性免疫反应的白细胞共同抗原（LCA）的情况下排除了癌，并证明了淋巴细胞的性质的一些细胞。电镜下可见淋巴细胞变性和平滑肌细胞空泡化。研究的7个开放性膀胱切除术标本中没有一个显示这种印戒细胞变化。结论：TURP标本中的慢性前列腺炎区域通常显示退化的淋巴细胞和间质细胞，其印戒外观偶尔可以模仿癌。这是TURP手术引起的伪影。
Histologic study of 20 consecutive cases of transurethral prostatectomy (TURP) showed aggregates of signet ring cells in the stroma in all but one case. They were usually associated with dense lymphocytic infiltrates, but occasionally they infiltrated the fibromuscular stroma and mimicked carcinoma. The absence of mucin and of immunoreactivity for prostate-specific acid phosphatase (PSAP) and prostate-specific antigen (PSA) and the focal positive immunoreaction for leukocyte common antigen (LCA) ruled out carcinoma and demonstrated the lymphocytic nature of some of the cells. Ultrastructurally, degenerated lymphocytes as well as vacuolated smooth cells were noted. None of the seven open prostatectomy specimens studied revealed this signet ring cell change. It is concluded that areas of chronic prostatitis in TURP specimens usually show degenerated lymphocytes and stromal cells with signet ring appearance that occasionally can mimic carcinoma. This is an artifact induced by the TURP procedure.