The anterobithorax and bithorax mutations of the bithorax complex.

The anterobithorax and bithorax mutations of the bithorax complex.
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双胸复合体的前胸和双胸突变。

DOI:
10.1002/j.1460-2075.1986.tb04497.x
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发表时间:
1986
期刊:
The EMBO Journal
影响因子:
--
通讯作者:
W. Bender
W. Bender
中科院分区:
--
文献类型:
--
作者:
M. Peifer;W. Bender

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前胸腺(abx)和前胸腺(bx)基因共同指导果蝇后第二胸腺和前第三胸腺的发育。我们鉴定了19个abx和bx等位基因的表型和DNA病变。abx和bx突变在其DNA损伤的性质和位置上都不同,在Ultrabithorax转录单元的一个相对较小的区域内形成两个簇。表型与DNA损伤之间的相关性表明,该区域存在两种或更多的遗传元件,与Ultrabithorax转录本不同。突变体变换不严格服从段或准段边界。大多数bx突变是由于插入了可移动元素gypsy。这些等位基因的强度以规则的方式变化,取决于吉普赛元素的位置和方向。根据这些结果,我们提出了吉普赛元素作用和双胸复杂表达的模型。
The anterobithorax (abx) and bithorax (bx) genes together direct the development of the posterior second and anterior third thoracic segments of the fruit fly. We have characterized the phenotypes and DNA lesions of 19 abx and bx alleles. abx and bx mutations differ both in the nature and location of their DNA lesions, forming two clusters within a relatively small region of the Ultrabithorax transcription unit. Correlation between phenotype and DNA lesion suggests the presence of two or more genetic elements in this region distinct from the Ultrabithorax transcript. Mutant transformations do not strictly obey segmental or parasegmental boundaries. Most of the bx mutations result from insertions of the mobile element gypsy. The strength of these alleles varies in a regular way dependent on the position and orientation of the gypsy element. We propose models for gypsy element action and bithorax complex expression in the light of these results.
DOI: --
发表时间: 1982
期刊: Progress in clinical and biological research
影响因子: --
作者:
Lewis,EB
通讯作者: Lewis,EB