Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
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DOI：
10.3390/polym11081254
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发表时间：
2019-08-01
期刊：
影响因子：
5
通讯作者：
Nakanishi, Jun
中科院分区：
文献类型：
--
作者：
Yamamoto, Shota;Yamada, Takafumi;Nakanishi, Jun
本研究研究了一系列由定义良好的两亲性二嵌段共聚物组成的聚合体的结构-功能关系。构建模块是通过点击疏水聚合物，预先合成的，和市售的具有光可切割的2-硝基苯基化合物，具有炔和马来酰亚胺功能的聚乙二醇合成的。所有测试的聚合体即使在足够的光照射后仍保持其空心结构。然而，捕获的阴离子荧光团的释放速率高度依赖于分子量和疏水聚合物的类型，以及带电端基的存在与否。此外，疏水壳内含有2-亚硝基苄基光解残基的聚合体在完全光解后表现出光诱导的有效载荷释放。结果表明，负载释放是由光诱导疏水壳的渗透性变化介导的，而不是由其整体结构的分解介导的。
In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation. Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the molecular weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures.