The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus
The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus
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DOI：
10.1007/s00592-011-0287-8
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发表时间：
2012-02-01
影响因子：
3.8
通讯作者：
Taniguchi, Nobuyuki
中科院分区：
文献类型：
--
作者：
Miyamoto, Michiaki;Kotani, Kazuhiko;Taniguchi, Nobuyuki
超声测量颈总动脉（CCA）直径在糖尿病实践中的临床意义还没有充分确定。本研究的目的是探讨超声CCA直径与动脉粥样硬化的措施和糖尿病视网膜病变的2型糖尿病（T2DM）患者的微血管并发症的关系。这项基于医院的横断面研究纳入了102例T2DM患者（男性：65%，平均年龄：57岁），这些患者无明显颈动脉狭窄，无心血管或重度肾脏疾病病史。测量患者的吸烟情况、体重指数、血压、血红蛋白A1c、血清低密度脂蛋白胆固醇、颈动脉超声指标（CCA直径、内膜中层厚度（IMT）、斑块积分）。心踝血管指数（CAVI）和糖尿病视网膜病变的存在也进行了评估。颈总动脉直径与IMT及斑块积分呈显著正相关。CAVI与平均IMT、斑块评分和CCA直径呈显著正相关，而糖尿病视网膜病变与CCA直径呈显著正相关，但与平均IMT或斑块评分无关。在调整多种混杂因素后，这些结果没有改变。CCA直径可作为动脉粥样硬化和糖尿病视网膜病变的有用标志物，特别是，在T2DM患者中，CCA直径可作为比颈动脉IMT和斑块评分更清楚地与糖尿病视网膜病变相关的标志物。
The clinical significance of the diameter of the common carotid artery (CCA) measured ultrasonographically in diabetic practice has not been sufficiently established. The objective of this study was to investigate the relationship of the ultrasonic CCA diameter with atherosclerotic measures and diabetic retinopathy as a microvascular complication in patients with type 2 diabetes mellitus (T2DM). This hospital-based cross-sectional study included 102 patients with T2DM (men: 65%, mean age: 57 years) who had no apparent carotid arterial stenosis and no history of cardiovascular or severe renal disease. The current smoking status, body mass index, blood pressure, hemoglobin A1c, serum low-density lipoprotein cholesterol, and ultrasonic measures of carotid arteries (CCA diameter, intima-media thickness (IMT), plaque score) were measured. The cardio-ankle vascular index (CAVI) and the presence of diabetic retinopathy were also assessed. The CCA diameter showed a significant positive correlation with the mean IMT or plaque score. The CAVI had a significant positive correlation with the mean IMT, plaque score, and CCA diameter, while diabetic retinopathy had a significant positive correlation with the CCA diameter, but not the mean IMT or plaque score. These results were unaltered after adjusting for multiple confounders. The CCA diameter may serve as a useful marker for atherosclerosis and diabetic retinopathy, and in particular, may be a marker associated with diabetic retinopathy more clearly than the carotid IMT and plaque score, in patients with T2DM.