Prion protein and cancers.
Prion protein and cancers.
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DOI：
10.1093/abbs/gmu019
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发表时间：
2014-06
影响因子：
3.7
通讯作者：
Xiaowen Yang;Yan Zhang;Lihua Zhang;T. He;Jie Zhang;Chaoyang Li
中科院分区：
文献类型：
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作者：
Xiaowen Yang;Yan Zhang;Lihua Zhang;T. He;Jie Zhang;Chaoyang Li
朊蛋白（PrP（C））是一种高度保守的细胞表面糖蛋白，在哺乳动物中广泛表达。PrP（C）的表达在朊病毒疾病的发病机制中起着关键作用，但PrP（C）的正常生理功能仍不完全清楚。基于在细胞模型中的研究，已将过多的功能归因于PrP（C）。本文综述了PrP（C）在细胞生理学中发挥的潜在作用，并重点讨论了其对肿瘤发生的贡献。
The normal cellular prion protein, PrP(C) is a highly conserved and widely expressed cell surface glycoprotein in all mammals. The expression of PrP is pivotal in the pathogenesis of prion diseases; however, the normal physiological functions of PrP(C) remain incompletely understood. Based on the studies in cell models, a plethora of functions have been attributed to PrP(C). In this paper, we reviewed the potential roles that PrP(C) plays in cell physiology and focused on its contribution to tumorigenesis.