SHORT-COURSE ANTIBIOTIC-THERAPY FOR RIGHT-SIDED ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS-AUREUS IN INJECTION-DRUG USERS
SHORT-COURSE ANTIBIOTIC-THERAPY FOR RIGHT-SIDED ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS-AUREUS IN INJECTION-DRUG USERS
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DOI：
10.7326/0003-4819-121-11-199412010-00009
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发表时间：
1994-12-01
影响因子：
39.2
通讯作者：
DINUBILE, MJ
中科院分区：
文献类型：
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作者：
DINUBILE, MJ
由金黄色葡萄球菌引起的右心内膜炎是注射毒品的常见并发症。幸运的是，这种感染的预后与标准方案治疗4至6周的肠外抗葡萄球菌抗生素是有利的。然而，在许多情况下，一旦吸毒者感觉好些，他们在完成整个抗生素治疗过程之前就离开医院。这个问题刺激了人们对通过在青霉素酶抗性青霉素中加入氨基糖苷类抗生素来缩短抗生素治疗时间的兴趣。来自体外协同研究和心内膜炎动物模型的数据表明，S。联合治疗比单一治疗能更快地根除金黄色葡萄球菌。已经发表了三项前瞻性、非随机临床试验的报告，支持使用一周疗程的青霉素酶耐药青霉素和氨基糖苷类抗生素治疗由甲氧西林-阿替西汀S引起的单纯右侧心内膜炎。金黄色葡萄球菌感染
Right-sided endocarditis caused by Staphylococcus aureus is a frequent complication of injection drug use. Fortunately, the prognosis for this infection when treated with the standard regimen of 4 to 6 weeks od parenteral antistaphylococcal antibiotics is favorable. Nevertheless, in many cases, once drug users feel better, they leave the hospital against medical advice before completing the full course of antibiotic therapy. This problem has stimulated interest in shortening the duration of antibiotic treatment by adding an aminoglycoside antibiotic to a penicillinase-resistant penicillin. Data from in vitro synergy studies and animal models of endocarditis suggest that S. aureus can be eradicated more quickly by combination therapy than by monotherapy. Reports of three prospective, nonrandomized clinical trials have been published that support the use of a a-week course of a penicillinase-resistant penicillin and an aminoglycoside antibiotic to treat uncomplicated, exclusively right-sided endocarditis caused by methicillin-susceptibte S. aureus in injection drug users.