Intracellular self-assembly of supramolecular gelators to selectively kill cells of interest
Intracellular self-assembly of supramolecular gelators to selectively kill cells of interest
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DOI：
10.1038/s41428-020-0335-8
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发表时间：
2020-04
期刊：
影响因子：
2.8
通讯作者：
T. Maruyama;W. K. Restu
中科院分区：
文献类型：
--
作者：
T. Maruyama;W. K. Restu
上世纪末以来超分子化学的重大进展包括超分子凝胶的发展。特别是，合成小胶凝剂分子的时空自组装因其能够在指定空间、指定时间实现某些功能特性而引起了越来越多的关注。与疏水部分缀合的肽是超分子胶凝剂（低分子量胶凝剂，LMWG）的典型例子，它可以被设计或编程以自组装形成纳米纤维/纳米片，以响应广泛的刺激或微环境。在过去的十年中，几个研究小组报告说，在活细胞内部或活细胞表面上实现的小胶凝剂分子的自组装诱导了选择性细胞死亡，这将导致一种新的治疗方法或新的细胞选择工具。这篇重点综述概述了活细胞内控制细胞命运的小胶凝剂分子的自组装。
The significant progress in supramolecular chemistry since the end of last century includes the development of supramolecular gels. In particular, the spatiotemporal self-assembly of synthetic small gelator molecules has attracted increasing attention owing to their ability to achieve certain functional properties in a designated space at a designated time. Peptides conjugated with hydrophobic moieties are typical examples of supramolecular gelators (low molecular weight gelators, LMWGs), which can be designed or programmed to self-assemble to form nanofibers/nanosheets in response to a broad range of stimuli or microenvironments. In the last decade, several groups have reported that the self-assembly of small gelator molecules achieved inside living cells or on the surfaces of living cells induced selective cell death, which would lead to a novel therapeutic approach or a novel cell selection tool. This focused review outlines the self-assembly of small gelator molecules inside living cells that control cell fate.