Prefrontal involvement in "temporal bridging" and timing movement
Prefrontal involvement in "temporal bridging" and timing movement
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DOI：
10.1016/s0028-3932(98)00038-4
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发表时间：
1998-12-01
期刊：
影响因子：
2.6
通讯作者：
Bullmore, E
中科院分区：
文献类型：
--
作者：
Rubia, K;Overmeyer, S;Bullmore, E
仅与暂时性延迟有关的大脑活动很少使用现代大脑成像进行研究。在这项研究中，我们利用功能磁共振成像的时间分辨率，通过正弦回归分析，描述了两种不同的感觉运动同步任务在健康受试者中诱导的不同神经激活模式，它们的运动前延迟不同，分别为0.6a和5 S。短事件率条件下需要有节奏的敲击，而长事件率条件下需要间歇运动的定时。左侧头侧前额叶皮质、内侧额叶皮质：SMA和缘上回在低频同步过程中表现出MR信号强度增加，这表明这些大脑区域形成了一个分布式神经网络，用于认知时间管理过程，如时间估计和运动输出计时。内侧额叶皮质在两种同步状态下表现出双相反应模式，推测反映了与频率无关的运动输出相关的注意。正如预测的那样，感觉运动区和视觉关联区在高频同步过程中显示出更高的MR信号强度。(C)1998爱思唯尔科学有限公司。保留所有权利。
Brain activity exclusively related to a temporal delay has rarely been investigated using modern brain imaging. In this study we exploited the temporal resolution of functional magnetic resonance imaging (fMRI) to characterise, by sinusoidal regression analysis, differential neuroactivation patterns induced in healthy subjects by two sensorimotor synchronization tasks different in their premovement delay of either 0.6 a or 5 s. The short event rate condition required rhythmic tapping, while the long event rate condition required timing of intermittent movements. Left rostral prefrontal cortex, medial frontal cortex: SMA and supramarginal gyrus demonstrated increased MR signal intensity during low frequency synchronization, suggesting that these brain regions form a distributed neural network for cognitive time management processes, such as time estimation and motor output timing. Medial frontal cortex showed a biphasic pattern of response during both synchronization conditions, presumably reflecting frequency-independent motor output related attention. As predicted, sensorimotor and visual association areas demonstrated increased MR signal intensity during high frequency synchronization. (C) 1998 Elsevier Science Ltd. All rights reserved.