INTERACTION OF CANNABIDIOL AND ALCOHOL IN HUMANS
INTERACTION OF CANNABIDIOL AND ALCOHOL IN HUMANS
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DOI：
10.1007/bf00431988
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发表时间：
1979-01-01
影响因子：
3.4
通讯作者：
AVELINOLACERDA, L
中科院分区：
文献类型：
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作者：
CONSROE, P;CARLINI, EA;AVELINOLACERDA, L
在双盲、交叉、随机设计中，6名男性和4名女性健康志愿者被给予口服安慰剂（葡萄糖胶囊和橙子汁）、大麻二酚（CBD 200 mg胶囊和橙子汁）、酒精（1 g/kg，在橙子汁和葡萄糖胶囊中）和CBD（200 mg胶囊）加酒精（1 g/kg，在橙子汁中）。治疗间隔1周。测量的参数是手指敲击测试（运动性能），取消和差分能力倾向测试（心理性能），1分钟的时间生产任务，主观效果（66项形容词对语义差异）和呼气测醉器估计血液酒精水平。与安慰剂相比，酒精和酒精加CBD，但不是单独的CBD，产生了运动和精神表现的显着损害，高估了时间生产和主观反应，表明他们的醉酒和赤字的准确自我感知。与单独给予酒精相比，酒精加CBD的组合导致血液酒精水平显着降低;观察到2种酒精条件的药理作用之间几乎没有差异。CBD是大麻的一种主要成分，对运动和精神表现和影响的不活动性也延伸到它与酒精的相互作用。
Six male and 4 female healthy volunteers were given oral placebo (glucose capsule and orange juice), cannabidiol (CBD 200 mg capsule and orange juice), alcohol (1 g/kg in orange juice and glucose capsule) and CBD (200 mg capsule) plus alcohol (1 g/kg in orange juice) in a double-blind, crossover, randomized design. Treatments were spaced 1 wk apart. Parameters measured were a finger tap test (motor performance), cancellation and differential aptitude tests (psychomotor performance), a 1 min time production task, subjective effects (66 item adjective-pair semantic differential) and breathalyzer estimations of blood alcohol levels. Compared to placebo, alcohol and alcohol plus CBD, but not CBD alone, produced significant impairments of motor and psychomotor performances, overestimations of time production and subjective responses indicating an accurate self-perception of their intoxication and deficits. The combination of alcohol plus CBD resulted in significantly lower blood alcohol levels compared to alcohol given alone; there were few differences observed between the pharmacological effects of the 2 alcohol conditions. The inactivity of CBD, a major marijuana constituent, on motor and mental performance and effects also extends to its interaction with alcohol.