Phages amid antimicrobial resistance
Phages amid antimicrobial resistance
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DOI：
10.1080/1040841x.2019.1691973
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发表时间：
2019-11
影响因子：
6.5
通讯作者：
J. M. Mohan Raj;I. Karunasagar
中科院分区：
文献类型：
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作者：
J. M. Mohan Raj;I. Karunasagar
抗菌药物耐药性水平的不断提高在卫生部门造成了混乱，一些感染对抗生素治疗没有反应。在过去的几年里，寻找替代策略已经将噬菌体视为潜在的治疗方法。有报道称，抗生素已成功用于治疗危及生命的感染。噬菌体也是移动的元件，其在不同细菌物种之间和内部交换基因，并且显著地解释物种之间和物种内部的菌株差异。宏基因组学分析和保守检测方法的差距未能准确说明噬菌体在抗菌素耐药性中的作用。最近的研究集中在噬菌体在病原体适应新宿主和出现多药耐药性中的作用，这是噬菌体治疗的一个重要问题。这篇文章提出了一个全面的考虑权衡的几率噬菌体疗法与噬菌体介导的抗菌素耐药性。
Abstract Increasing levels of resistance to antimicrobial agents have created chaos in the health sector, with several infections not responding to antibiotic treatments. Search for alternative strategies has looked at bacteriophages as potential therapeutics and in the last couple of years. There are reports of phages being successfully used to treat life-threatening infections. Phages are also mobile elements that exchange genes between and within different bacterial species and account significantly for strain differences across and within a species. A gap in metagenomics analysis and conservative methods of detection have failed to give an accurate account of the role of bacteriophages in antimicrobial resistance. Recent studies have focussed on the role of bacteriophages in the adaptation of pathogens to new hosts and the emergence of multidrug-resistance, which are a significant concern against phage therapy. This article presents a comprehensive account of weighing the odds of phage therapy verses phage-mediated antimicrobial resistance.