Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
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DOI：
10.20900/immunometab20210031
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发表时间：
2021-10-04
期刊：
影响因子：
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通讯作者：
Thornton CA
中科院分区：
文献类型：
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作者：
Jenkins BJ;Rees A;Jones N;Thornton CA
妊娠的特征是在妊娠过程中发生代谢变化，以支持胎儿的生长和发育。这些代谢变化可以分为两个不同的阶段：初始合成代谢阶段，以准备足够的底物和能量储存，然后在分解代谢阶段分解和使用，以满足母亲，胎盘和胎儿的能量需求。免疫稳态的动态调整也是妊娠的一个特征，可能与此时能量底物利用的变化有关。随着细胞代谢越来越多地被认为是免疫细胞表型和功能的关键决定因素，我们考虑母体代谢的变化如何可能有助于怀孕期间T细胞的可塑性。
Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy.