Course of illness in depressive and bipolar disorders - Naturalistic study, 1994-1999
Course of illness in depressive and bipolar disorders - Naturalistic study, 1994-1999
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DOI：
10.1192/bjp.185.5.372
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发表时间：
2004-11-01
影响因子：
10.5
通讯作者：
Andersen, PK
中科院分区：
文献类型：
--
作者：
Kessing, LV;Hansen, MG;Andersen, PK
背景在过去的十年中，新型抗抑郁药的使用越来越多。这些药物可能会增加依从性和减少周期加速的风险在情感disorder.Aims目的是调查自然的纵向病程在抑郁症或双相情感障碍患者使用最近推出的drugs.Method复发率导致住院治疗后连续发作的病例登记研究，包括所有入院的原发性情感障碍患者在丹麦在1994-1999年期间。总之，9417例患者有抑郁症的诊断和1106例患者有躁狂症或双相情感障碍的诊断，在第一次出院。结果复发率导致住院治疗的抑郁症和双相情感障碍的前几次发作的数量增加。然而，发作的影响对男性来说并不显著。复发率并没有下降，在研究period.Conclusions的过程中，严重抑郁症和双相情感障碍一直保持大致相同，尽管引入了新的治疗。资金在确认中详细说明。
Background Newer antidepressants have increasingly been used during the past decade. These drugs may increase compliance and reduce the risk of cycle acceleration in affective disorders.Aims To investigate the naturalistic longitudinal course of illness in patients with depressive or bipolar disorder following the use of recently introduced drugs.Method The rates of relapse leading to hospitalisation after successive episodes were calculated in a case register study including all hospital admissions of patients with primary affective disorder in Denmark during 1994-1999. Altogether, 9417 patients had a diagnosis of depressive disorder and 1106 patients had a diagnosis of mania or bipolar disorder, at first-ever discharge.Results The rate of relapse leading to hospitalisation increased with the number of previous episodes in both depressive and bipolar disorders. However, the effect of episodes was not significant for men. The rate of relapse did not decline during the study period.Conclusions The course of severe depressive and bipolar disorders has remained roughly the same despite introduction of new treatments.Declaration of interest None. Funding detailed in Acknowledgement.