Use of Statins and Risk of Hospitalization With Dementia A Danish Population-based Case-control Study
Use of Statins and Risk of Hospitalization With Dementia A Danish Population-based Case-control Study
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DOI：
10.1097/wad.0b013e318180f55b
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发表时间：
2009-01-01
影响因子：
2.1
通讯作者：
Johnsen, Soren Paaske
中科院分区：
文献类型：
--
作者：
Horsdal, Henriette Thisted;Olesen, Anne Vingard;Johnsen, Soren Paaske
一些流行病学研究表明，他汀类药物使用者患痴呆症的风险降低。我们在1991年至2005年期间在丹麦北部的4个县进行了一项基于人群的病例对照研究，评估了与使用他汀类药物相关的痴呆症住院风险。我们使用国家患者登记处、丹麦精神病学中央登记处和民事登记系统的数据，确定了11,039例痴呆症患者和110,340名年龄匹配和性别匹配的人群对照。使用基于人群的处方数据库识别在痴呆入院前填写的他汀类药物处方。我们使用条件Logistic回归分析来计算与使用他汀类药物相关的痴呆症住院的相对风险，并以未使用他汀类药物为参照组。我们发现他汀类药物使用者患痴呆症的住院风险总体上降低了(调整后的优势比：0.67，95%可信区间：0.60-0.75)。在不同的子分析中，与使用他汀类药物相关的风险降低仍然很明显，然而，我们发现他汀类药物处方数量和痴呆症住院风险之间没有明确的剂量-反应模式。总而言之，我们发现服用他汀类药物的患者因痴呆症住院的风险降低，然而，这种联系是否是因果关系仍有待澄清。
Several epidemiologic studies have indicated reduced risk of dementia among users of statins. We assessed the risk of hospitalization with dementia associated with use of statins in a population-based case-control study in 4 Northern Danish counties in the period 1991 to 2005. We identified 11,039 cases with dementia and 110,340 age- matched and sex-matched population controls using data from the National Patient Registry, the Danish Psychiatric Central Register, and the Civil Registration System. Prescriptions for statins filled before the admission for dementia were identified using population-based prescription databases. We used conditional logistic regression analysis to compute relative risk of hospitalization with dementia associated with use of statins using nonusers as reference group. We found an overall reduced risk of hospitalization with dementia among statin users (adjusted odds ratio: 0.67, 95% confidence intervals: 0.60-0.75). The reduce risk associated with statin use remained robust in various subanalyses, however, we found no clear dose-response pattern between the number of filled prescriptions for statin and the risk of hospitalization with dementia. In conclusion, we found a reduced risk of hospitalization with dementia among users of statins, however, whether this association is causal remains to be clarified.