Differential encoding of losses and gains in the human striatum.
Differential encoding of losses and gains in the human striatum.
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DOI：
10.1523/jneurosci.0400-07.2007
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发表时间：
2007-05-02
期刊：
影响因子：
--
通讯作者：
Dolan R
中科院分区：
文献类型：
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作者：
Seymour B;Daw N;Dayan P;Singer T;Dolan R
关于人类货币预测和决策的研究强调了纹状体在编码预测错误以获得经济奖励方面的作用。然而，人们对大脑如何编码经济损失知之甚少。利用巴甫洛夫条件反射对同时包含经济回报和损失机会的结果进行视觉提示，我们发现纹状体激活反映了两者的正符号预测误差。此外，我们显示纹状体内的功能分离，更多的前部区域显示出对奖励的相对选择性，而更多的后部区域则显示出对损失的相对选择性。这些发现反映了啮齿动物中报道的前后价特异性梯度，并认可纹状体在有关财务损失的厌恶动机学习中的作用，说明了功能和解剖学与主要厌恶结果（例如疼痛）的一致性。
Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.