Diagnostic value of microRNAs in breast cancer: a meta-analysis.
Diagnostic value of microRNAs in breast cancer: a meta-analysis.
复制标题
DOI：
--
复制
发表时间：
2017
影响因子：
3.3
通讯作者：
Z. Xin;H-Q. Yang;X-W Wang;Qinghua Zhang
中科院分区：
文献类型：
--
作者：
Z. Xin;H-Q. Yang;X-W Wang;Qinghua Zhang
目的探讨微rna异常对乳腺癌诊断准确性的价值。材料与方法我们检索PubMed、Embase、EBSCO和Cochrane图书馆，通过文献筛选和质量评估，获取有关乳腺癌患者microRNA表达的文献，从纳入的研究中提取数据，并使用Stata 14.0分析数据进行meta分析。结果14项英文研究符合纳入标准。经meta分析纳入的研究获得较高的敏感性、特异性和诊断优势比，合并OR值为17.96 (95% CI: 11.42 ~ 28.42)，敏感性为0.85 (95% CI: 0.81 ~ 0.88)，特异性为0.77 (95% CI: 0.69 ~ 0.82)，诊断优势比为18 (95% CI: 12 ~ 29)，曲线下工作特征面积为0.88 （95% CI: 0.85 ~ 0.91）。结论microrna可作为乳腺癌诊断的临床辅助参考指标。
OBJECTIVE To explore the value of diagnosis accuracy of aberrant microRNAs in breast cancer. MATERIALS AND METHODS We searched PubMed, Embase, EBSCO and the Cochrane Library, accessing to the case of articles about microRNA expression in breast carcinoma patients after literature screening and quality assessment, extracting data from included studies and using Stata 14.0 analysis data for meta-analysis. RESULTS 14 English studies met the inclusion criteria. After meta-analysis for included studies obtained high sensitivity and specificity and diagnostic odds ratio, the combined OR value is 17.96 (95% CI: 11.42-28.42), sensitivity is 0.85 (95% CI: 0.81-0.88), specificity is 0.77 (95% CI: 0.69-0.82), diagnostic odds ratio is 18 (95% CI: 12-29), operating characteristic area under the curve is 0.88 (95% CI: 0.85-0.91). CONCLUSIONS The microRNAs can be used as a clinical auxiliary reference index for diagnosis of breast cancer.